rheumatoid arthritis experimental study

Li Z, Hu J, Bao C, et al. Baricitinib in patients with rheumatoid arthritis with inadequate response to methotrexate: results from a phase 3 study. Clin Exp Rheumatol 2020;38:732-741. PubMed

Systematic review of robust experimental models of rheumatoid arthritis for basic research. Author links open overlay panel Lin Ye 1, Hu Mingyue 1, Zhang Feng 1, Dai Zongshun 1, Xie Ying 2, Cai Xiong 1, Liu Liang 2. ... Arthritis Research & Therapy, 6 (6) (2004), pp. R544-550. View in Scopus Google Scholar

The abovementioned studies about the mechanism of miRNAs have shown promising results in experimental models of arthritis, and their efficacy needs more clinical trials to prove. Consisting of more than 200 nucleotides in length, lncRNAs are identified as long non-coding RNAs and are widely expressed in various tissues of the human body.

Genovese MC, Weinblatt ME, Aelion JA. et al. ABT-122, a bispecific dual variable domain immunoglobulin targeting tumor necrosis factor and interleukin-17a, in patients with rheumatoid arthritis with an inadequate response to methotrexate: a randomized, double-blind study. Arthritis Rheumatol 2018; 70:1710-20.

Cell states associated with rheumatoid arthritis versus osteoarthritis in a previous study of more than 5,000 synovial cells were also associated with rheumatoid arthritis in this dataset ...

Rheumatoid arthritis (RA) is an autoimmune, inflammatory condition that causes progressive destruction of joints. Most patients have only transient responses to current therapies, and very few ...

Forest plots visualizing ORs ± 95% CI for achieving ACR 20/50/70 responses in rheumatoid arthritis phase 2 studies compared to phase 3 studies. Each row represents data for the three main ...

Rheumatoid arthritis (RA) is a systemic inflammatory disease that can cause impaired functional ability, chronic pain, and increased mortality rates if not properly treated [].Methotrexate (MTX) is the most commonly used first-line therapeutic choice for RA due to its well-known safety profile and demonstrated effectiveness in reducing disease activity and preventing joint damage [2,3,4].

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with a complex pathological mechanism involving autoimmune response, local inflammation and bone destruction. Metabolic pathways play an important role in immune-related diseases and their immune responses. The pathogenesis of ...

The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, dose-ranging study. Arthritis Rheumatol. 2015; 67 (10):2591-600.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent articular inflammation and joint damage. RA was first described over 200 years ago; however, its etiology and pathophysiology remain insufficiently understood. The current treatment of RA is mainly empirical or based on the current understanding of ...

Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation through cell death and proinflammatory cytokine production. This multicenter, randomized, double-blind (sponsor-unblinded), placebo-controlled, experimental medicine study evaluated the safety, pharmacokinetics (PK), and preliminary efficacy of GSK2982772, a RIPK1 inhibitor, in moderate to severe rheumatoid ...

Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic autoimmune disease that affects the connective tissue and primarily the joints. If not treated, RA ultimately leads to progressive cartilage and bone degeneration. The etiology of the pathogenesis of RA is unknown, demonstrating heterogeneity in its clinical presentation, and is ...

Rheumatoid arthritis prevention studies provide an important experimental framework for generating deeper insights into risk stratification and for refining trial design in the future. To this end, a research agenda is suggested, together with some considerations for imaging and for biological sampling. This commentary concludes with some of ...

Rheumatoid arthritis affects one in 50 people, with about 456,000 Australians living with the autoimmune disease A Queensland-based study is focusing on improving the gut microbiome by using 'live ...

Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of ...

Rheumatoid arthritis patients getting little or no relief from conventional small-molecule drugs and injectable biologic drugs saw substantial improvement in their condition from daily use of an experimental compound in a large 24-week study led by a Stanford University School of Medicine investigator.. A paper describing the results of the double-blind, randomized phase-3 clinical trial was ...

The purpose of this study is to get synovial tissue from patients with rheumatoid arthritis by minimally invasive ultrasound guided biopsy, for the purpose of identifying the processes that are responsible for the cause of the disease. A Study to Evaluate Inflammation of the Heart Muscle Tissue in Patients with Rheumatoid Arthritis Rochester, MN.

Notably, resolvin D1 is detected in synovial fluid from patients with RA and can accelerate the resolution of experimental arthritis 8. Altogether, the results of the study by Alivernini et al. 1 ...

Basic research in the division includes models of rheumatoid arthritis and systemic lupus erythematosus as well as investigations into how diseases develop. Scientists work with biospecimens from people with rheumatoid arthritis, systemic lupus erythematosus, inflammatory myositis, vasculitis and scleroderma.

This Editorial refers to 'Effects of oral contraceptives and menopausal hormone therapy on the risk of rheumatoid arthritis: a prospective cohort study' by Hadizadeh et al. 2024;63:2101-8. The impact of sex hormones on rheumatic diseases such as rheumatoid arthritis (RA) is well-known.

Objectives Viruses have been considered as important participants in the development of rheumatoid arthritis (RA). However, the profile of enteric virome and its role in RA remains elusive. This study aimed to investigate the atlas and involvement of virome in RA pathogenesis. Methods Faecal samples from 30 pairs of RA and healthy siblings that minimise genetic interferences were collected for ...

Introduction. Rheumatoid arthritis (RA) is a chronic immune-mediated multisystemic disease that mainly localizes to the joints. It is the most common systemic inflammatory rheumatic disease (1, 2) and it is associated with considerable morbidity and disability, as well as increased mortality ().In the last decades, the prognosis of RA patients has been dramatically improved by the expansion of ...

Introduction The role of uric acid (UA) on bone metabolism is controversially discussed. Higher UA levels have been associated with higher T-scores and a reduced incidence of fractures in postmenopausal women. However, in the context of rheumatoid arthritis (RA), the role of UA remains unclear. This pilot study aimed to investigate the association of UA levels with bone mineral density in RA ...

Rheumatoid arthritis (RA) patients sometimes exhibit different levels of improvement in health assessment questionnaire-disability index (HAQ-DI) and subjective pain visual analogue score (VAS) even after achieving low disease activities (LDA). This study aimed to identify factors associated with improvement in HAQ-DI and pain VAS among those who achieved LDA.

The inflammatory activity in the body caused by rheumatoid arthritis is linked to specific cognitive impairments, finds a small comparative study, published in the open access journal RMD ...

Several studies on experimental murine arthritis have clearly demonstrated the importance of the intestinal microbiota in the pathogenesis of arthritis (Table 1).When mice are reared in germ-free ...

Background: There is growing evidence of bidirectional associations between rheumatoid arthritis and adverse pregnancy outcomes (APOs) in observational studies, but little is known about the causal direction of these associations. Therefore, we explored the potential causal relationships between rheumatoid arthritis and APOs using a bidirectional two-sample Mendelian randomization (MR) in ...

Rheumatoid arthritis; Schizophrenia; ... Experimental AI method boosts doctors' ability to diagnose cancers and precancers of the esophagus ... The 3,117 patients in the study were all over the ...

Rheumatoid arthritis can be prevented, a breakthrough Lancet study has found. Weekly injections of the drug, abatacept, cut the risk of developing the auto-immune disease by 80 per cent during a ...