• Patient Care & Health Information
  • Tests & Procedures
  • Feminizing surgery

Feminizing surgery, also called gender-affirming surgery or gender-confirmation surgery, involves procedures that help better align the body with a person's gender identity. Feminizing surgery includes several options, such as top surgery to increase the size of the breasts. That procedure also is called breast augmentation. Bottom surgery can involve removal of the testicles, or removal of the testicles and penis and the creation of a vagina, labia and clitoris. Facial procedures or body-contouring procedures can be used as well.

Not everybody chooses to have feminizing surgery. These surgeries can be expensive, carry risks and complications, and involve follow-up medical care and procedures. Certain surgeries change fertility and sexual sensations. They also may change how you feel about your body.

Your health care team can talk with you about your options and help you weigh the risks and benefits.

Products & Services

  • A Book: Mayo Clinic Family Health Book
  • Available Sexual Health Solutions at Mayo Clinic Store
  • Newsletter: Mayo Clinic Health Letter — Digital Edition

Why it's done

Many people seek feminizing surgery as a step in the process of treating discomfort or distress because their gender identity differs from their sex assigned at birth. The medical term for this is gender dysphoria.

For some people, having feminizing surgery feels like a natural step. It's important to their sense of self. Others choose not to have surgery. All people relate to their bodies differently and should make individual choices that best suit their needs.

Feminizing surgery may include:

  • Removal of the testicles alone. This is called orchiectomy.
  • Removal of the penis, called penectomy.
  • Removal of the testicles.
  • Creation of a vagina, called vaginoplasty.
  • Creation of a clitoris, called clitoroplasty.
  • Creation of labia, called labioplasty.
  • Breast surgery. Surgery to increase breast size is called top surgery or breast augmentation. It can be done through implants, the placement of tissue expanders under breast tissue, or the transplantation of fat from other parts of the body into the breast.
  • Plastic surgery on the face. This is called facial feminization surgery. It involves plastic surgery techniques in which the jaw, chin, cheeks, forehead, nose, and areas surrounding the eyes, ears or lips are changed to create a more feminine appearance.
  • Tummy tuck, called abdominoplasty.
  • Buttock lift, called gluteal augmentation.
  • Liposuction, a surgical procedure that uses a suction technique to remove fat from specific areas of the body.
  • Voice feminizing therapy and surgery. These are techniques used to raise voice pitch.
  • Tracheal shave. This surgery reduces the thyroid cartilage, also called the Adam's apple.
  • Scalp hair transplant. This procedure removes hair follicles from the back and side of the head and transplants them to balding areas.
  • Hair removal. A laser can be used to remove unwanted hair. Another option is electrolysis, a procedure that involves inserting a tiny needle into each hair follicle. The needle emits a pulse of electric current that damages and eventually destroys the follicle.

Your health care provider might advise against these surgeries if you have:

  • Significant medical conditions that haven't been addressed.
  • Behavioral health conditions that haven't been addressed.
  • Any condition that limits your ability to give your informed consent.

Like any other type of major surgery, many types of feminizing surgery pose a risk of bleeding, infection and a reaction to anesthesia. Other complications might include:

  • Delayed wound healing
  • Fluid buildup beneath the skin, called seroma
  • Bruising, also called hematoma
  • Changes in skin sensation such as pain that doesn't go away, tingling, reduced sensation or numbness
  • Damaged or dead body tissue — a condition known as tissue necrosis — such as in the vagina or labia
  • A blood clot in a deep vein, called deep vein thrombosis, or a blood clot in the lung, called pulmonary embolism
  • Development of an irregular connection between two body parts, called a fistula, such as between the bladder or bowel into the vagina
  • Urinary problems, such as incontinence
  • Pelvic floor problems
  • Permanent scarring
  • Loss of sexual pleasure or function
  • Worsening of a behavioral health problem

Certain types of feminizing surgery may limit or end fertility. If you want to have biological children and you're having surgery that involves your reproductive organs, talk to your health care provider before surgery. You may be able to freeze sperm with a technique called sperm cryopreservation.

How you prepare

Before surgery, you meet with your surgeon. Work with a surgeon who is board certified and experienced in the procedures you want. Your surgeon talks with you about your options and the potential results. The surgeon also may provide information on details such as the type of anesthesia that will be used during surgery and the kind of follow-up care that you may need.

Follow your health care team's directions on preparing for your procedures. This may include guidelines on eating and drinking. You may need to make changes in the medicine you take and stop using nicotine, including vaping, smoking and chewing tobacco.

Because feminizing surgery might cause physical changes that cannot be reversed, you must give informed consent after thoroughly discussing:

  • Risks and benefits
  • Alternatives to surgery
  • Expectations and goals
  • Social and legal implications
  • Potential complications
  • Impact on sexual function and fertility

Evaluation for surgery

Before surgery, a health care provider evaluates your health to address any medical conditions that might prevent you from having surgery or that could affect the procedure. This evaluation may be done by a provider with expertise in transgender medicine. The evaluation might include:

  • A review of your personal and family medical history
  • A physical exam
  • A review of your vaccinations
  • Screening tests for some conditions and diseases
  • Identification and management, if needed, of tobacco use, drug use, alcohol use disorder, HIV or other sexually transmitted infections
  • Discussion about birth control, fertility and sexual function

You also may have a behavioral health evaluation by a health care provider with expertise in transgender health. That evaluation might assess:

  • Gender identity
  • Gender dysphoria
  • Mental health concerns
  • Sexual health concerns
  • The impact of gender identity at work, at school, at home and in social settings
  • The role of social transitioning and hormone therapy before surgery
  • Risky behaviors, such as substance use or use of unapproved hormone therapy or supplements
  • Support from family, friends and caregivers
  • Your goals and expectations of treatment
  • Care planning and follow-up after surgery

Other considerations

Health insurance coverage for feminizing surgery varies widely. Before you have surgery, check with your insurance provider to see what will be covered.

Before surgery, you might consider talking to others who have had feminizing surgery. If you don't know someone, ask your health care provider about support groups in your area or online resources you can trust. People who have gone through the process may be able to help you set your expectations and offer a point of comparison for your own goals of the surgery.

What you can expect

Facial feminization surgery.

Facial feminization surgery may involve a range of procedures to change facial features, including:

  • Moving the hairline to create a smaller forehead
  • Enlarging the lips and cheekbones with implants
  • Reshaping the jaw and chin
  • Undergoing skin-tightening surgery after bone reduction

These surgeries are typically done on an outpatient basis, requiring no hospital stay. Recovery time for most of them is several weeks. Recovering from jaw procedures takes longer.

Tracheal shave

A tracheal shave minimizes the thyroid cartilage, also called the Adam's apple. During this procedure, a small cut is made under the chin, in the shadow of the neck or in a skin fold to conceal the scar. The surgeon then reduces and reshapes the cartilage. This is typically an outpatient procedure, requiring no hospital stay.

Top surgery

Breast incisions for breast augmentation

  • Breast augmentation incisions

As part of top surgery, the surgeon makes cuts around the areola, near the armpit or in the crease under the breast.

Placement of breast implants or tissue expanders

  • Placement of breast implants or tissue expanders

During top surgery, the surgeon places the implants under the breast tissue. If feminizing hormones haven't made the breasts large enough, an initial surgery might be needed to have devices called tissue expanders placed in front of the chest muscles.

Hormone therapy with estrogen stimulates breast growth, but many people aren't satisfied with that growth alone. Top surgery is a surgical procedure to increase breast size that may involve implants, fat grafting or both.

During this surgery, a surgeon makes cuts around the areola, near the armpit or in the crease under the breast. Next, silicone or saline implants are placed under the breast tissue. Another option is to transplant fat, muscles or tissue from other parts of the body into the breasts.

If feminizing hormones haven't made the breasts large enough for top surgery, an initial surgery may be needed to place devices called tissue expanders in front of the chest muscles. After that surgery, visits to a health care provider are needed every few weeks to have a small amount of saline injected into the tissue expanders. This slowly stretches the chest skin and other tissues to make room for the implants. When the skin has been stretched enough, another surgery is done to remove the expanders and place the implants.

Genital surgery

Anatomy before and after penile inversion

  • Anatomy before and after penile inversion

During penile inversion, the surgeon makes a cut in the area between the rectum and the urethra and prostate. This forms a tunnel that becomes the new vagina. The surgeon lines the inside of the tunnel with skin from the scrotum, the penis or both. If there's not enough penile or scrotal skin, the surgeon might take skin from another area of the body and use it for the new vagina as well.

Anatomy before and after bowel flap procedure

  • Anatomy before and after bowel flap procedure

A bowel flap procedure might be done if there's not enough tissue or skin in the penis or scrotum. The surgeon moves a segment of the colon or small bowel to form a new vagina. That segment is called a bowel flap or conduit. The surgeon reconnects the remaining parts of the colon.

Orchiectomy

Orchiectomy is a surgery to remove the testicles. Because testicles produce sperm and the hormone testosterone, an orchiectomy might eliminate the need to use testosterone blockers. It also may lower the amount of estrogen needed to achieve and maintain the appearance you want.

This type of surgery is typically done on an outpatient basis. A local anesthetic may be used, so only the testicular area is numbed. Or the surgery may be done using general anesthesia. This means you are in a sleep-like state during the procedure.

To remove the testicles, a surgeon makes a cut in the scrotum and removes the testicles through the opening. Orchiectomy is typically done as part of the surgery for vaginoplasty. But some people prefer to have it done alone without other genital surgery.

Vaginoplasty

Vaginoplasty is the surgical creation of a vagina. During vaginoplasty, skin from the shaft of the penis and the scrotum is used to create a vaginal canal. This surgical approach is called penile inversion. In some techniques, the skin also is used to create the labia. That procedure is called labiaplasty. To surgically create a clitoris, the tip of the penis and the nerves that supply it are used. This procedure is called a clitoroplasty. In some cases, skin can be taken from another area of the body or tissue from the colon may be used to create the vagina. This approach is called a bowel flap procedure. During vaginoplasty, the testicles are removed if that has not been done previously.

Some surgeons use a technique that requires laser hair removal in the area of the penis and scrotum to provide hair-free tissue for the procedure. That process can take several months. Other techniques don't require hair removal prior to surgery because the hair follicles are destroyed during the procedure.

After vaginoplasty, a tube called a catheter is placed in the urethra to collect urine for several days. You need to be closely watched for about a week after surgery. Recovery can take up to two months. Your health care provider gives you instructions about when you may begin sexual activity with your new vagina.

After surgery, you're given a set of vaginal dilators of increasing sizes. You insert the dilators in your vagina to maintain, lengthen and stretch it. Follow your health care provider's directions on how often to use the dilators. To keep the vagina open, dilation needs to continue long term.

Because the prostate gland isn't removed during surgery, you need to follow age-appropriate recommendations for prostate cancer screening. Following surgery, it is possible to develop urinary symptoms from enlargement of the prostate.

Dilation after gender-affirming surgery

This material is for your education and information only. This content does not replace medical advice, diagnosis and treatment. If you have questions about a medical condition, always talk with your health care provider.

Narrator: Vaginal dilation is important to your recovery and ongoing care. You have to dilate to maintain the size and shape of your vaginal canal and to keep it open.

Jessi: I think for many trans women, including myself, but especially myself, I looked forward to one day having surgery for a long time. So that meant looking up on the internet what the routines would be, what the surgery entailed. So I knew going into it that dilation was going to be a very big part of my routine post-op, but just going forward, permanently.

Narrator: Vaginal dilation is part of your self-care. You will need to do vaginal dilation for the rest of your life.

Alissa (nurse): If you do not do dilation, your vagina may shrink or close. If that happens, these changes might not be able to be reversed.

Narrator: For the first year after surgery, you will dilate many times a day. After the first year, you may only need to dilate once a week. Most people dilate for the rest of their life.

Jessi: The dilation became easier mostly because I healed the scars, the stitches held up a little bit better, and I knew how to do it better. Each transgender woman's vagina is going to be a little bit different based on anatomy, and I grew to learn mine. I understand, you know, what position I needed to put the dilator in, how much force I needed to use, and once I learned how far I needed to put it in and I didn't force it and I didn't worry so much on oh, did I put it in too far, am I not putting it in far enough, and I have all these worries and then I stress out and then my body tenses up. Once I stopped having those thoughts, I relaxed more and it was a lot easier.

Narrator: You will have dilators of different sizes. Your health care provider will determine which sizes are best for you. Dilation will most likely be painful at first. It's important to dilate even if you have pain.

Alissa (nurse): Learning how to relax the muscles and breathe as you dilate will help. If you wish, you can take the pain medication recommended by your health care team before you dilate.

Narrator: Dilation requires time and privacy. Plan ahead so you have a private area at home or at work. Be sure to have your dilators, a mirror, water-based lubricant and towels available. Wash your hands and the dilators with warm soapy water, rinse well and dry on a clean towel. Use a water-based lubricant to moisten the rounded end of the dilators. Water-based lubricants are available over-the-counter. Do not use oil-based lubricants, such as petroleum jelly or baby oil. These can irritate the vagina. Find a comfortable position in bed or elsewhere. Use pillows to support your back and thighs as you lean back to a 45-degree angle. Start your dilation session with the smallest dilator. Hold a mirror in one hand. Use the other hand to find the opening of your vagina. Separate the skin. Relax through your hips, abdomen and pelvic floor. Take slow, deep breaths. Position the rounded end of the dilator with the lubricant at the opening to your vaginal canal. The rounded end should point toward your back. Insert the dilator. Go slowly and gently. Think of its path as a gentle curving swoop. The dilator doesn't go straight in. It follows the natural curve of the vaginal canal. Keep gentle down and inward pressure on the dilator as you insert it. Stop when the dilator's rounded end reaches the end of your vaginal canal. The dilators have dots or markers that measure depth. Hold the dilator in place in your vaginal canal. Use gentle but constant inward pressure for the correct amount of time at the right depth for you. If you're feeling pain, breathe and relax the muscles. When time is up, slowly remove the dilator, then repeat with the other dilators you need to use. Wash the dilators and your hands. If you have increased discharge following dilation, you may want to wear a pad to protect your clothing.

Jessi: I mean, it's such a strange, unfamiliar feeling to dilate and to have a dilator, you know to insert a dilator into your own vagina. Because it's not a pleasurable experience, and it's quite painful at first when you start to dilate. It feels much like a foreign body entering and it doesn't feel familiar and your body kind of wants to get it out of there. It's really tough at the beginning, but if you can get through the first month, couple months, it's going to be a lot easier and it's not going to be so much of an emotional and uncomfortable experience.

Narrator: You need to stay on schedule even when traveling. Bring your dilators with you. If your schedule at work creates challenges, ask your health care team if some of your dilation sessions can be done overnight.

Alissa (nurse): You can't skip days now and do more dilation later. You must do dilation on schedule to keep vaginal depth and width. It is important to dilate even if you have pain. Dilation should cause less pain over time.

Jessi: I hear that from a lot of other women that it's an overwhelming experience. There's lots of emotions that are coming through all at once. But at the end of the day for me, it was a very happy experience. I was glad to have the opportunity because that meant that while I have a vagina now, at the end of the day I had a vagina. Yes, it hurts, and it's not pleasant to dilate, but I have the vagina and it's worth it. It's a long process and it's not going to be easy. But you can do it.

Narrator: If you feel dilation may not be working or you have any questions about dilation, please talk with a member of your health care team.

Research has found that gender-affirming surgery can have a positive impact on well-being and sexual function. It's important to follow your health care provider's advice for long-term care and follow-up after surgery. Continued care after surgery is associated with good outcomes for long-term health.

Before you have surgery, talk to members of your health care team about what to expect after surgery and the ongoing care you may need.

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Feminizing surgery care at Mayo Clinic

  • Tangpricha V, et al. Transgender women: Evaluation and management. https://www.uptodate.com/ contents/search. Accessed Aug. 16, 2022.
  • Erickson-Schroth L, ed. Surgical transition. In: Trans Bodies, Trans Selves: A Resource by and for Transgender Communities. 2nd ed. Kindle edition. Oxford University Press; 2022. Accessed Aug. 17, 2022.
  • Coleman E, et al. Standards of care for the health of transgender and gender diverse people, version 8. International Journal of Transgender Health. 2022; doi:10.1080/26895269.2022.2100644.
  • AskMayoExpert. Gender-affirming procedures (adult). Mayo Clinic; 2022.
  • Nahabedian, M. Implant-based breast reconstruction and augmentation. https://www.uptodate.com/contents/search. Accessed Aug. 17, 2022.
  • Erickson-Schroth L, ed. Medical transition. In: Trans Bodies, Trans Selves: A Resource by and for Transgender Communities. 2nd ed. Kindle edition. Oxford University Press; 2022. Accessed Aug. 17, 2022.
  • Ferrando C, et al. Gender-affirming surgery: Male to female. https://www.uptodate.com/contents/search. Accessed Aug. 17, 2022.
  • Doctors & Departments
  • Care at Mayo Clinic

Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.

  • Opportunities

Mayo Clinic Press

Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press .

  • Mayo Clinic on Incontinence - Mayo Clinic Press Mayo Clinic on Incontinence
  • The Essential Diabetes Book - Mayo Clinic Press The Essential Diabetes Book
  • Mayo Clinic on Hearing and Balance - Mayo Clinic Press Mayo Clinic on Hearing and Balance
  • FREE Mayo Clinic Diet Assessment - Mayo Clinic Press FREE Mayo Clinic Diet Assessment
  • Mayo Clinic Health Letter - FREE book - Mayo Clinic Press Mayo Clinic Health Letter - FREE book

5X Challenge

Thanks to generous benefactors, your gift today can have 5X the impact to advance AI innovation at Mayo Clinic.

  • Type 2 Diabetes
  • Heart Disease
  • Digestive Health
  • Multiple Sclerosis
  • Diet & Nutrition
  • Health Insurance
  • Public Health
  • Patient Rights
  • Caregivers & Loved Ones
  • End of Life Concerns
  • Health News
  • Thyroid Test Analyzer
  • Doctor Discussion Guides
  • Hemoglobin A1c Test Analyzer
  • Lipid Test Analyzer
  • Complete Blood Count (CBC) Analyzer
  • What to Buy
  • Editorial Process
  • Meet Our Medical Expert Board

Preparation and Procedures Involved in Gender Affirmation Surgeries

If you or a loved one are considering gender affirmation surgery , you are probably wondering what steps you must go through before the surgery can be done. Let's look at what is required to be a candidate for these surgeries, the potential positive effects and side effects of hormonal therapy, and the types of surgeries that are available.

Gender affirmation surgery, also known as gender confirmation surgery, is performed to align or transition individuals with gender dysphoria to their true gender.

A transgender woman, man, or non-binary person may choose to undergo gender affirmation surgery.

The term "transexual" was previously used by the medical community to describe people who undergo gender affirmation surgery. The term is no longer accepted by many members of the trans community as it is often weaponized as a slur. While some trans people do identify as "transexual", it is best to use the term "transgender" to describe members of this community.

Transitioning

Transitioning may involve:

  • Social transitioning : going by different pronouns, changing one’s style, adopting a new name, etc., to affirm one’s gender
  • Medical transitioning : taking hormones and/or surgically removing or modifying genitals and reproductive organs

Transgender individuals do not need to undergo medical intervention to have valid identities.  

Reasons for Undergoing Surgery

Many transgender people experience a marked incongruence between their gender and their assigned sex at birth.   The American Psychiatric Association (APA) has identified this as gender dysphoria.

Gender dysphoria is the distress some trans people feel when their appearance does not reflect their gender. Dysphoria can be the cause of poor mental health or trigger mental illness in transgender people.

For these individuals, social transitioning, hormone therapy, and gender confirmation surgery permit their outside appearance to match their true gender.  

Steps Required Before Surgery

In addition to a comprehensive understanding of the procedures, hormones, and other risks involved in gender-affirming surgery, there are other steps that must be accomplished before surgery is performed. These steps are one way the medical community and insurance companies limit access to gender affirmative procedures.

Steps may include:

  • Mental health evaluation : A mental health evaluation is required to look for any mental health concerns that could influence an individual’s mental state, and to assess a person’s readiness to undergo the physical and emotional stresses of the transition.  
  • Clear and consistent documentation of gender dysphoria
  • A "real life" test :   The individual must take on the role of their gender in everyday activities, both socially and professionally (known as “real-life experience” or “real-life test”).

Firstly, not all transgender experience physical body dysphoria. The “real life” test is also very dangerous to execute, as trans people have to make themselves vulnerable in public to be considered for affirmative procedures. When a trans person does not pass (easily identified as their gender), they can be clocked (found out to be transgender), putting them at risk for violence and discrimination.

Requiring trans people to conduct a “real-life” test despite the ongoing violence out transgender people face is extremely dangerous, especially because some transgender people only want surgery to lower their risk of experiencing transphobic violence.

Hormone Therapy & Transitioning

Hormone therapy involves taking progesterone, estrogen, or testosterone. An individual has to have undergone hormone therapy for a year before having gender affirmation surgery.  

The purpose of hormone therapy is to change the physical appearance to reflect gender identity.

Effects of Testosterone

When a trans person begins taking testosterone , changes include both a reduction in assigned female sexual characteristics and an increase in assigned male sexual characteristics.

Bodily changes can include:

  • Beard and mustache growth  
  • Deepening of the voice
  • Enlargement of the clitoris  
  • Increased growth of body hair
  • Increased muscle mass and strength  
  • Increase in the number of red blood cells
  • Redistribution of fat from the breasts, hips, and thighs to the abdominal area  
  • Development of acne, similar to male puberty
  • Baldness or localized hair loss, especially at the temples and crown of the head  
  • Atrophy of the uterus and ovaries, resulting in an inability to have children

Behavioral changes include:

  • Aggression  
  • Increased sex drive

Effects of Estrogen

When a trans person begins taking estrogen , changes include both a reduction in assigned male sexual characteristics and an increase in assigned female characteristics.

Changes to the body can include:

  • Breast development  
  • Loss of erection
  • Shrinkage of testicles  
  • Decreased acne
  • Decreased facial and body hair
  • Decreased muscle mass and strength  
  • Softer and smoother skin
  • Slowing of balding
  • Redistribution of fat from abdomen to the hips, thighs, and buttocks  
  • Decreased sex drive
  • Mood swings  

When Are the Hormonal Therapy Effects Noticed?

The feminizing effects of estrogen and the masculinizing effects of testosterone may appear after the first couple of doses, although it may be several years before a person is satisfied with their transition.   This is especially true for breast development.

Timeline of Surgical Process

Surgery is delayed until at least one year after the start of hormone therapy and at least two years after a mental health evaluation. Once the surgical procedures begin, the amount of time until completion is variable depending on the number of procedures desired, recovery time, and more.

Transfeminine Surgeries

Transfeminine is an umbrella term inclusive of trans women and non-binary trans people who were assigned male at birth.

Most often, surgeries involved in gender affirmation surgery are broken down into those that occur above the belt (top surgery) and those below the belt (bottom surgery). Not everyone undergoes all of these surgeries, but procedures that may be considered for transfeminine individuals are listed below.

Top surgery includes:

  • Breast augmentation  
  • Facial feminization
  • Nose surgery: Rhinoplasty may be done to narrow the nose and refine the tip.
  • Eyebrows: A brow lift may be done to feminize the curvature and position of the eyebrows.  
  • Jaw surgery: The jaw bone may be shaved down.
  • Chin reduction: Chin reduction may be performed to soften the chin's angles.
  • Cheekbones: Cheekbones may be enhanced, often via collagen injections as well as other plastic surgery techniques.  
  • Lips: A lip lift may be done.
  • Alteration to hairline  
  • Male pattern hair removal
  • Reduction of Adam’s apple  
  • Voice change surgery

Bottom surgery includes:

  • Removal of the penis (penectomy) and scrotum (orchiectomy)  
  • Creation of a vagina and labia

Transmasculine Surgeries

Transmasculine is an umbrella term inclusive of trans men and non-binary trans people who were assigned female at birth.

Surgery for this group involves top surgery and bottom surgery as well.

Top surgery includes :

  • Subcutaneous mastectomy/breast reduction surgery.
  • Removal of the uterus and ovaries
  • Creation of a penis and scrotum either through metoidioplasty and/or phalloplasty

Complications and Side Effects

Surgery is not without potential risks and complications. Estrogen therapy has been associated with an elevated risk of blood clots ( deep vein thrombosis and pulmonary emboli ) for transfeminine people.   There is also the potential of increased risk of breast cancer (even without hormones, breast cancer may develop).

Testosterone use in transmasculine people has been associated with an increase in blood pressure, insulin resistance, and lipid abnormalities, though it's not certain exactly what role these changes play in the development of heart disease.  

With surgery, there are surgical risks such as bleeding and infection, as well as side effects of anesthesia . Those who are considering these treatments should have a careful discussion with their doctor about potential risks related to hormone therapy as well as the surgeries.  

Cost of Gender Confirmation Surgery

Surgery can be prohibitively expensive for many transgender individuals. Costs including counseling, hormones, electrolysis, and operations can amount to well over $100,000. Transfeminine procedures tend to be more expensive than transmasculine ones. Health insurance sometimes covers a portion of the expenses.

Quality of Life After Surgery

Quality of life appears to improve after gender-affirming surgery for all trans people who medically transition. One 2017 study found that surgical satisfaction ranged from 94% to 100%.  

Since there are many steps and sometimes uncomfortable surgeries involved, this number supports the benefits of surgery for those who feel it is their best choice.

A Word From Verywell

Gender affirmation surgery is a lengthy process that begins with counseling and a mental health evaluation to determine if a person can be diagnosed with gender dysphoria.

After this is complete, hormonal treatment is begun with testosterone for transmasculine individuals and estrogen for transfeminine people. Some of the physical and behavioral changes associated with hormonal treatment are listed above.

After hormone therapy has been continued for at least one year, a number of surgical procedures may be considered. These are broken down into "top" procedures and "bottom" procedures.

Surgery is costly, but precise estimates are difficult due to many variables. Finding a surgeon who focuses solely on gender confirmation surgery and has performed many of these procedures is a plus.   Speaking to a surgeon's past patients can be a helpful way to gain insight on the physician's practices as well.

For those who follow through with these preparation steps, hormone treatment, and surgeries, studies show quality of life appears to improve. Many people who undergo these procedures express satisfaction with their results.

Bizic MR, Jeftovic M, Pusica S, et al. Gender dysphoria: Bioethical aspects of medical treatment . Biomed Res Int . 2018;2018:9652305. doi:10.1155/2018/9652305

American Psychiatric Association. What is gender dysphoria? . 2016.

The World Professional Association for Transgender Health. Standards of care for the health of transsexual, transgender, and gender-nonconforming people . 2012.

Tomlins L. Prescribing for transgender patients . Aust Prescr . 2019;42(1): 10–13.  doi:10.18773/austprescr.2019.003

T'sjoen G, Arcelus J, Gooren L, Klink DT, Tangpricha V. Endocrinology of transgender medicine . Endocr Rev . 2019;40(1):97-117. doi:10.1210/er.2018-00011

Unger CA. Hormone therapy for transgender patients . Transl Androl Urol . 2016;5(6):877-884.  doi:10.21037/tau.2016.09.04

Seal LJ. A review of the physical and metabolic effects of cross-sex hormonal therapy in the treatment of gender dysphoria . Ann Clin Biochem . 2016;53(Pt 1):10-20.  doi:10.1177/0004563215587763

Schechter LS. Gender confirmation surgery: An update for the primary care provider . Transgend Health . 2016;1(1):32-40. doi:10.1089/trgh.2015.0006

Altman K. Facial feminization surgery: current state of the art . Int J Oral Maxillofac Surg . 2012;41(8):885-94.  doi:10.1016/j.ijom.2012.04.024

Therattil PJ, Hazim NY, Cohen WA, Keith JD. Esthetic reduction of the thyroid cartilage: A systematic review of chondrolaryngoplasty . JPRAS Open. 2019;22:27-32. doi:10.1016/j.jpra.2019.07.002

Top H, Balta S. Transsexual mastectomy: Selection of appropriate technique according to breast characteristics . Balkan Med J . 2017;34(2):147-155. doi:10.4274/balkanmedj.2016.0093

Chan W, Drummond A, Kelly M. Deep vein thrombosis in a transgender woman . CMAJ . 2017;189(13):E502-E504.  doi:10.1503/cmaj.160408

Streed CG, Harfouch O, Marvel F, Blumenthal RS, Martin SS, Mukherjee M. Cardiovascular disease among transgender adults receiving hormone therapy: A narrative review . Ann Intern Med . 2017;167(4):256-267. doi:10.7326/M17-0577

Hashemi L, Weinreb J, Weimer AK, Weiss RL. Transgender care in the primary care setting: A review of guidelines and literature . Fed Pract . 2018;35(7):30-37.

Van de grift TC, Elaut E, Cerwenka SC, Cohen-kettenis PT, Kreukels BPC. Surgical satisfaction, quality of life, and their association after gender-affirming aurgery: A follow-up atudy . J Sex Marital Ther . 2018;44(2):138-148. doi:10.1080/0092623X.2017.1326190

American Society of Plastic Surgeons. Gender confirmation surgeries .

American Psychological Association. Transgender people, gender identity, and gender expression .

Colebunders B, Brondeel S, D'Arpa S, Hoebeke P, Monstrey S. An update on the surgical treatment for transgender patients . Sex Med Rev . 2017 Jan;5(1):103-109. doi:10.1016/j.sxmr.2016.08.001

  • Reconstructive Procedures

Gender Confirmation Surgeries Transgender-Specific Facial, Top and Bottom Procedures

What surgical options are available to transgender and gender non-conforming patients? Gender confirmation surgeries, also known as gender affirmation surgeries, are performed by a multispecialty team that typically includes board-certified plastic surgeons. The goal is to give transgender individuals the physical appearance and functional abilities of the gender they know themselves to be. Listed below are many of the available procedures for transwomen (MTF) and transmen (FTM) to aid in their journey.

Facial Feminization Surgery

Transfeminine top surgery, transfeminine bottom surgery, facial masculinization surgery, transmasculine top surgery, transmasculine bottom surgery, on the blog.

gender confirmation surgery vs gender reassignment

Facial feminization surgery is a combination of procedures designed to soften the facial features and feminize the face. There are many procedures that are available to feminize the face.

  • Facial feminization surgery improves gender dysphoria in trans women Josef Hadeed, MD, FACS
  • The impact of COVID-19 on gender dysphoria patients Cristiane Ueno, MD

On The Vlog

gender confirmation surgery vs gender reassignment

Facial feminization surgery is always tailored to the individual, but as ASPS member Justine Lee, MD, PhD, explains there are general characteristics such as hairline, brow bones, cheeks and jawline that many patients note and plastic surgeons plan for.

  • Gender Affirmation Top Surgery with Dr. Julie Hansen

Find Your Surgeon

Patient care center, before & after photos.

Logo

Video Gallery

3d animations, patient safety.

Masks Strongly Recommended but Not Required in Maryland, Starting Immediately

Due to the downward trend in respiratory viruses in Maryland, masking is no longer required but remains strongly recommended in Johns Hopkins Medicine clinical locations in Maryland. Read more .

  • Vaccines  
  • Masking Guidelines
  • Visitor Guidelines  

A transgender woman in a hospital gown having a conversation with a doctor, a transgender man.

Gender Affirmation Surgeries

Featured Expert:

Fan Liang

Fan Liang, M.D.

Surgeries are not required for gender affirmation, but many patients choose to undergo one or more surgical procedures. Talk with your doctor to discuss what surgical options may be right for you. The following is an overview of gender affirmation surgeries.

  • Penile construction (phalloplasty/metoidioplasty) : This surgical procedure can include removal of the vagina (vaginectomy), reconstruction of the urethra and penile reconstruction. Surgeons may use either vaginal tissue or tissue from another part of the body to construct the penis.
  • Vaginal construction (vaginoplasty) : This surgical procedure is a multistage process during which surgeons may remove the penis (penectomy) and the testes (orchiectomy), if still present, and use tissues from the penis to construct the vagina, the clitoris (clitoroplasty) and the labia (labiaplasty).
  • Top surgery is surgery that removes or augments breast tissue and reshapes the chest to create a more masculine or feminine appearance for transgender and nonbinary people.
  • Facial gender surgery can include a variety of procedures to create more feminine features , like reshaping the nose; brow lift (or forehead lift); chin, cheek and jaw reshaping; Adam’s apple reduction; lip augmentation; hairline restoration; and earlobe reduction. 
  • Facial gender surgery can also include a series of procedures to create more masculine features , such as forehead lengthening and augmentation; cheek augmentation;  reshaping the nose  and chin;  jaw augmentation ; and thyroid cartilage enhancement to construct an Adam’s apple.
  • Hysterectomy : This surgical procedure includes the removal of the uterus and ovaries (oophorectomy). There are options for oocyte storage and fertility preservation that you may want to discuss with your doctor. 
  • Some people may combine this procedure with a scrotectomy , which is surgery to remove all or part of the scrotum. For others, the skin of the scrotum can be used in vulvoplasty or vaginoplasty ― the surgical construction of a vulva or vagina.
  • The procedure reduces testosterone production and may eliminate the need for continuing therapy with estrogen and androgen-suppressing medications. Your health care practitioner will discuss options such as sperm freezing before orchiectomy that can preserve your ability to become a biological parent.

Recovery After Gender Affirmation Surgeries

Recovery time from a gender affirmation surgery or procedure varies, depending on the procedure. Talk to your doctor about what you can expect.

Treatment Caring for Transgender Patients

Fearing discrimination and hostility, transgender people are often reluctant to seek care. Discover how Paula Neira, Program Director of LGBTQ+ Equity and Education, Johns Hopkins Medicine Office of Diversity, Inclusion and Health Equity, is working to ensure that all patients — regardless of gender identity — are treated with dignity and respect.

Find a Doctor

Specializing In:

  • Transgender Health
  • Gender Affirmation Surgery

Find a Treatment Center

  • Center for Transgender and Gender Expansive Health

Find Additional Treatment Centers at:

  • Howard County Medical Center
  • Sibley Memorial Hospital
  • Suburban Hospital

No image available

Request an Appointment

No image available

Transgender Health: What You Need to Know

Asian transgender man meeting with doctor, private follow up appointment at doctor home.

Facial Masculinization Surgery

gender affirmation services

Gender Affirmation: Do I Need Surgery?

Related Topics

  • LGBTQ Health
  • Gender Affirmation

Jump to content

Updated visitor policies

Other michigan medicine sites.

  • About Michigan Medicine
  • UofMHealth.org
  • Medical School
  • Find a Clinical Trial

Michigan Medicine logo - Home

Michigan Medicine

Federated search page form block, quick links.

  • Patient Portal Login
  • For Health Providers
  • Maps & Directions

Gender Confirmation Surgery

The University of Michigan Health System offers procedures for surgical gender transition.  Working together, the surgical team of the Comprehensive Gender Services Program, which includes specialists in plastic surgery, urology and gynecology, bring expertise, experience and safety to procedures for our transgender patients.

Access to gender-related surgical procedures for patients is made through the University of Michigan Health System Comprehensive Gender Services Program .

The Comprehensive Gender Services Program adheres to the WPATH Standards of Care , including the requirement for a second-opinion prior to genital sex reassignment.

Available surgeries:

Male-to-Female:  Tracheal Shave  Breast Augmentation  Facial Feminization  Male-to-Female genital sex reassignment

Female-to-Male:  Hysterectomy, oophorectomy, vaginectomy Chest Reconstruction  Female-to-male genital sex reassignment

Sex Reassignment Surgeries (SRS)

At the University of Michigan Health System, we are dedicated to offering the safest proven surgical options for sex reassignment (SRS.)   Because sex reassignment surgery is just one step for transitioning people, the Comprehensive Gender Services Program has access to providers for mental health services, hormone therapy, pelvic floor physiotherapy, and speech therapy.  Surgical procedures are done by a team that includes, as appropriate, gynecologists, urologists, pelvic pain specialists and a reconstructive plastic surgeon. A multi-disciplinary team helps to best protect the health of the patient.

For patients receiving mental health and medical services within the University of Michigan Health System, the UMHS-CGSP will coordinate all care including surgical referrals.  For patients who have prepared for surgery elsewhere, the UMHS-CGSP will help organize the needed records, meet WPATH standards, and coordinate surgical referrals.  Surgical referrals are made through Sara Wiener the Comprehensive Gender Services Program Director.

Male-to-female sex reassignment surgery

At the University of Michigan, participants of the Comprehensive Gender Services Program who are ready for a male-to-female sex reassignment surgery will be offered a penile inversion vaginoplasty with a neurovascular neoclitoris.

During this procedure, a surgeon makes “like become like,” using parts of the original penis to create a sensate neo-vagina. The testicles are removed, a procedure called orchiectomy. The skin from the scrotum is used to make the labia. The erectile tissue of the penis is used to make the neoclitoris. The urethra is preserved and functional.

This procedure provides for aesthetic and functional female genitalia in one 4-5 hour operation.  The details of the procedure, the course of recovery, the expected outcomes, and the possible complications will be covered in detail during your surgical consultation. What to Expect: Vaginoplasty at Michigan Medicine .

Female-to-male sex reassignment

At the University of Michigan, participants of the Comprehensive Gender Services Program who are ready for a female-to-male sex reassignment surgery will be offered a phalloplasty, generally using the radial forearm flap method. 

This procedure, which can be done at the same time as a hysterectomy/vaginectomy, creates an aesthetically appropriate phallus and creates a urethera for standing urination.  Construction of a scrotum with testicular implants is done as a second stage.  The details of the procedure, the course of recovery, the expected outcomes, and the possible complications will be covered in detail during your surgical consultation.

Individuals who desire surgical procedures who have not been part of the Comprehensive Gender Services Program should contact the program office at (734) 998-2150 or email [email protected] . W e will assist you in obtaining what you need to qualify for surgery.

  • A to Z Guides

What Is Gender Affirmation Surgery?

gender confirmation surgery vs gender reassignment

Surgery to change the appearance of your body is a common choice for all kinds of people. There are many reasons that people might want to alter their appearance. For transgender or gender nonconforming people, making changes to their bodies is a way of affirming their identity.

A trans person can choose from multiple procedures to make their appearance match their self-identified gender identity. Doctors refer to this as gender "affirmation" surgery.

Trans people might decide to have surgery on their chest, genitals, or face. These surgeries are personal decisions, and each person makes their own choices about what is right for them.

Learn more about gender affirmation surgery and how it helps trans people.

What Does It Mean to Be Transgender or Nonbinary?

Transgender is a word to describe people whose gender identity or gender expression doesn't match the sex they were assigned at birth. Typically, parents and doctors assume a baby's gender based on the appearance of their genitals. But some people grow up and realize that their sense of who they are isn't aligned with how their bodies look. These people are considered transgender.

Trans people may identify as a different gender than what they were assigned at birth. For example, a child assigned male at birth may identify as female. Nonbinary people don't identify as either male or female. They may refer to themselves as "nonbinary" or "genderqueer."

There are many options for trans and nonbinary people to change their appearance so that how they look reflects who they are inside. Many trans people use clothing, hairstyles, or makeup to present a particular look. Some use hormone therapy to refine their secondary sex characteristics. Some people choose surgery that can change their bodies and faces permanently.

Facial Surgery

Facial plastic surgery is popular and accessible for all kinds of people in the U.S. It is not uncommon to have a nose job or a facelift . Cosmetic surgery is great for improving self-esteem and making people feel more like themselves. Trans people can use plastic surgery to adjust the shape of their faces to better reflect their gender identity.

Facial feminization. A person with a masculine face can have surgeries to make their face and neck look more feminine. These can be done in one procedure or through multiple operations. They might ask for:

  • Forehead contouring
  • Jaw reduction
  • Chin surgery
  • Hairline advancement
  • Cheek augmentation
  • Rhinoplasty
  • Lip augmentation
  • Adam's apple reduction

Facial masculinization. Someone with a feminine face can have surgery to make their face look more masculine. The doctor may do all the procedures at one time or plan multiple surgeries. Doctors usually offer:

  • Forehead lengthening
  • Jaw reshaping
  • Chin contouring
  • Adam's apple enhancement

Top Surgery

Breast surgeries are very common in America. The shorthand for breast surgeries is "top surgery." All kinds of people have operations on their breasts , and there are a lot of doctors who can do them. The surgeries that trans people have to change their chests are very similar to typical breast enhancement or breast removal operations.

Transfeminine. When a trans person wants a more feminine bustline, that's called transfeminine top surgery. It involves placing breast implants in a person's chest. It's the same operation that a doctor might do to enlarge someone's breasts or for breast reconstruction .

Transmasculine. Transmasculine top surgery is when a person wants a more masculine chest shape. It is similar to a mastectomy . The doctor removes the breast tissue to flatten the whole chest. The doctor can also contour the skin and reposition the nipples to look more like a typical man's chest.

Bottom Surgery

For people who want to change their genitals, some operations can do that. That is sometimes called bottom surgery. Those are complicated procedures that require doctors with a lot of experience with trans surgeries.

Transmasculine bottom surgery. Some transmasculine people want to remove their uterus and ovaries. They can choose to have a hysterectomy to do that. This reduces the level of female hormones in their bodies and stops their menstrual cycles.

If a person wants to change their external genitals, they can ask for surgery to alter the vaginal opening. A surgeon can also construct a penis for them. There are several techniques for doing this.

Metoidioplasty uses the clitoris and surrounding skin to create a phallus that can become erect and pass urine. A phalloplasty requires grafting skin from another part of the body into the genital region to create a phallus. People can also have surgery to make a scrotum with implants that mimic testicles. ‌

Transfeminine bottom surgery. People who want to reduce the level of male hormones in their bodies may choose to have their testicles removed. This is called an orchiectomy and can be done as an outpatient operation.

Vaginoplasty is an operation to construct a vagina . Doctors use the tissue from the penis and invert it into a person's pelvic area. The follow-up after a vaginoplasty involves using dilators to prevent the new vaginal opening from closing back up.

How Much Does Gender Affirmation Surgery Cost?

Some medical insurance companies will cover some or most parts of your gender-affirming surgery. But many might have certain "exclusions" listed in the plan. They might use language like "services related to sex change" or "sex reassignment surgery." These limitations may vary by state. It's best to reach out to your insurance company by phone or email to confirm the coverage or exclusions.

If your company does cover some costs, they may need a few documents before they approve it.

This can include:

  • A gender dysphoria diagnosis in your health records. It's a term used to describe the feeling you have when the sex you're assigned at birth does not match with your gender identity. A doctor can provide a note if it's necessary.
  • A letter of support from a mental health professional such as a social worker, psychiatrist , or a therapist.

Gender affirmation surgery can be very expensive. It's best to check with your insurance company to see what type of coverage you have.

If you're planning to pay out-of-pocket, prices may vary depending on the various specialists involved in your case. This can include surgeons, primary care doctors, anesthesiologists, psychiatrists, social workers, and counselors. The procedure costs also vary, and the total bill will include a number of charges, including hospital stay, anesthesia, counseling sessions, medications, and the procedures you elect to have.

Whether you choose facial, top, or bottom or a combination of these procedures, the total bill after your hospital stay can cost anywhere from $5,400 for chin surgery to well over $100,000 for multiple procedures.

Recovery and Mental Health After Gender Affirmation Surgery

Your recovery time may vary. It will depend on the type of surgery you have. But swelling can last anywhere from 2 weeks for facial surgery to up to 4 months or more if you opted for bottom surgery.

Talk to your doctor about when you can get back to your normal day-to-day routine. But in the meantime, make sure to go to your regular follow-up appointments with your doctor. This will help them make sure you're healing well post-surgery.

Most trans and nonbinary people who get gender affirmation surgery report that it improves their overall quality of life. In fact, over 94% of people who opt for surgery say they are satisfied with the results.

Folks who have mental health support before surgery tend to do better, too. One study found that after gender affirmation surgery, a person's need for mental health treatment went down by 8%.

Not all trans and nonbinary people choose to have gender affirmation surgery, or they may only have some of the procedures available. If you are considering surgery, speak with your primary care doctor to discuss what operations might be best for you.

Top doctors in ,

Find more top doctors on, related links.

  • Health A-Z News
  • Health A-Z Reference
  • Health A-Z Slideshows
  • Health A-Z Quizzes
  • Health A-Z Videos
  • WebMDRx Savings Card
  • Coronavirus (COVID-19)
  • Hepatitis C
  • Diabetes Warning Signs
  • Rheumatoid Arthritis
  • Morning-After Pill
  • Breast Cancer Screening
  • Psoriatic Arthritis Symptoms
  • Heart Failure
  • Multiple Myeloma
  • Types of Crohn's Disease

gender confirmation surgery vs gender reassignment

gender confirmation surgery vs gender reassignment

  • Health Care Home
  • Transgender Health Program

Gender Affirmation Surgery

The following pages will discuss body parts in medical terms. We recognize that medical language about bodies is based on binary sex categories and can be pathologizing. Inform your provider of the language you would like used to refer to your body.

Urgent or After Hours Issues

5pm-8am or Weekends

Call 801-581-2121

Ask for the plastic surgery resident on call

Non-Urgent Issues/Questions

Mon-Fri, 8 am-5 pm

Any bottom surgery: call plastic surgery at 801-581-7719

Urinary catheter issues: call urology at 801-213-2700 (option 2)

Following Professional Care Standards

We are a team of surgeons dedicated to developing a center of excellence for gender affirming surgery in the Mountain West. We are passionate about serving the transgender community in our area, and across the country.

Our surgical providers at University of Utah Health work together with other specialties in the Transgender Health Program to provide a coordinated, safe approach to medical and surgical care. All of our providers follow the World Professional Association for Transgender Health (WPATH) Standards of Care .

Start The Process

Because every gender journey is unique, we don’t assume what types of surgeries someone may choose. However there are a few steps you can take before any surgical appointment.

Attend a Free Patient Education Seminar

Every month we host patient education seminars for patients and families to meet providers in our Program and learn about the different services and requirements.

Call Your Insurance Company to Ask if Gender Affirming Surgery is a Covered Benefit

See all insurance information .

Complete New Patient Questionnaire

You will be asked to complete an intake questionnaire before your consultation. Our team will help you  set up a MyChart account  where you will have the ability to fill this out online.

These questionnaires help us provide gender affirming services unique to you and your needs. Although some of the information asked is used to understand if you will meet WPATH criteria, none of your answers will disqualify you from accessing care with our program. Our goal is to help you get the services and resources you need to feel fully aligned with your identity.

Letters of Support

All surgical services require between one to two letters of support. These should be provided by a master’s level mental health provider indicating your readiness for surgery and documentation of gender dysphoria. You do NOT need these letters of support until after your consultation, but we will need them prior to scheduling your surgery and submitting the prior authorization for your insurance.

You can download this  template letter of support  for your mental health provider that includes the criteria we need to submit your prior authorization.

Looking for a mental health provider? View  mental health  resources.

Transmasculine

Transfeminine, pre/post op photos & delayed surgery, surgery pre and post-op photos.

To protect our patients’ privacy, we do not post pre and post-operative photos on our website. However, when you schedule a consultation for any surgery you can request to see these photos at your consultation.

Delayed or Cancelled Surgery

Unfortunately, there are times when surgery will have to be delayed or cancelled. This is due to various reasons; however, our teams are here to ensure we can get you rescheduled for a new surgery date.  Find resources in the local Utah area and out of state .

Our Training

Before starting the gender affirming surgery program at University of Utah, our team travelled to sites across the country to compare different surgical techniques. 

We picked sites that are known for high volume and excellent outcomes:

  • Chicago, Illinois;
  • Portland, Oregon;  and
  • New York University. 

We have also participated in dissection courses, focusing in-depth on the anatomy of the pelvis and the changes made during gender affirming surgery.

In hopes of creating the best experience possible for our patients, we have also worked within the hospital community at U of U Health to educate all members of the hospital staff (intake clerks, nursing, food services, physical therapy, occupational therapy) with whom our patients will interact. 

Bringing a Team Approach to Our Patients’ Care

We have seen that a team approach allows us to handle any complication that arises and gives our gender affirming surgery patients easy access to their surgeons. 

We also have four surgeons involved in our phalloplasty and vaginoplasty surgeries. Having four surgeons involved in these surgeries allows us to continually fine-tune our approach, which helps us improve our patient's satisfaction with their outcomes. 

Our surgical team is passionate about providing the following services to all our patients:

  • high quality, compassionate health care to all our patients,
  • close follow-up,
  • transparent outcomes for patients, and
  • research designed to improve our care for all our patient.

Find a Transgender Health Doctor

Hear from our patients.

River Jude August in the snow

Gender Affirmation Does More Than Affirm—It Heals

When River Jude August arrived for surgery, they faced yet another challenge in their long journey to align their body with who they know they are. River, who identifies as agender—or outside the female/male binary—had already changed their legal gender to X. They had transitioned socially, opted for several medical treatments, and now faced their biggest surgery yet. River was about to undergo phalloplasty, the construction of a phallus.

Authentic Life Begins Thanks to Transgender Health Program

Jace was standing in the bra section of a clothing store with his mom when suddenly he began to cry. Jace hadn’t been the kind of kid who struggled with his gender identity from a young age. But when puberty hit and his body became more feminine, it didn’t feel right.

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • View all journals
  • Explore content
  • About the journal
  • Publish with us
  • Sign up for alerts
  • Review Article
  • Published: 12 April 2011

Gender reassignment surgery: an overview

  • Gennaro Selvaggi 1 &
  • James Bellringer 1  

Nature Reviews Urology volume  8 ,  pages 274–282 ( 2011 ) Cite this article

4001 Accesses

153 Citations

41 Altmetric

Metrics details

  • Pathogenesis
  • Reconstruction
  • Urogenital diseases

This article has been updated

Gender reassignment (which includes psychotherapy, hormonal therapy and surgery) has been demonstrated as the most effective treatment for patients affected by gender dysphoria (or gender identity disorder), in which patients do not recognize their gender (sexual identity) as matching their genetic and sexual characteristics. Gender reassignment surgery is a series of complex surgical procedures (genital and nongenital) performed for the treatment of gender dysphoria. Genital procedures performed for gender dysphoria, such as vaginoplasty, clitorolabioplasty, penectomy and orchidectomy in male-to-female transsexuals, and penile and scrotal reconstruction in female-to-male transsexuals, are the core procedures in gender reassignment surgery. Nongenital procedures, such as breast enlargement, mastectomy, facial feminization surgery, voice surgery, and other masculinization and feminization procedures complete the surgical treatment available. The World Professional Association for Transgender Health currently publishes and reviews guidelines and standards of care for patients affected by gender dysphoria, such as eligibility criteria for surgery. This article presents an overview of the genital and nongenital procedures available for both male-to-female and female-to-male gender reassignment.

The management of gender dysphoria consists of a combination of psychotherapy, hormonal therapy, and surgery

Psychiatric evaluation is essential before gender reassignment surgical procedures are undertaken

Gender reassignment surgery refers to the whole genital, facial and body procedures required to create a feminine or a masculine appearance

Sex reassignment surgery refers to genital procedures, namely vaginoplasty, clitoroplasty, labioplasty, and penile–scrotal reconstruction

In male-to-female gender dysphoria, skin tubes formed from penile or scrotal skin are the standard technique for vaginal construction

In female-to-male gender dysphoria, no technique is recognized as the standard for penile reconstruction; different techniques fulfill patients' requests at different levels, with a variable number of surgical technique-related drawbacks

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

195,33 € per year

only 16,28 € per issue

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

gender confirmation surgery vs gender reassignment

Similar content being viewed by others

gender confirmation surgery vs gender reassignment

Principles and outcomes of gender-affirming vaginoplasty

gender confirmation surgery vs gender reassignment

Sexual function of transgender assigned female at birth seeking gender affirming care: a narrative review

gender confirmation surgery vs gender reassignment

The effect of early puberty suppression on treatment options and outcomes in transgender patients

Change history, 26 april 2011.

In the version of this article initially published online, the statement regarding the frequency of male-to-female transsexuals was incorrect. The error has been corrected for the print, HTML and PDF versions of the article.

Meyer, W. 3rd. et al . The Harry Benjamin International Gender Dysphoria Association's standards of care for gender identity disorders, sixth version. World Professional Association for Transgender Health [online] , (2001).

Google Scholar  

Bakker, A., Van Kesteren, P., Gooren, L. & Bezemer, P. The prevalence of transsexualism in The Netherlands. Acta Psychiatr. Scand. 87 , 237–238 (1993).

Article   CAS   Google Scholar  

Selvaggi, G. et al . Gender identity disorder: general overview and surgical treatment for vaginoplasty in male-to-female transsexuals. Plast. Reconstr. Surg. 116 , 135e–145e (2005).

Article   Google Scholar  

Benjamin, H. (ed.) The Transsexual Phenomenon (Julian Press Inc., New York, 1966).

World Professional Association for Transgender Health [online] , (2010).

Zhou, J. N., Hofman, M. A., Gooren, L. J. & Swaab, D. F. A sex difference in the human brain and its relation to transsexuality. Nature 378 , 68–70 (1995).

Kruijver, F. P. et al . Male-to-female transsexuals have female neuron numbers in a limbic nucleus. J. Clin. Endocrinol. Metab. 85 , 2034–2041 (2000).

Swaab, D. F., Chun, W. C., Kruijver, F. P., Hofman, M. A. & Ishuina, T. A. Sexual differentiation of the human hypothalamus. Adv. Exp. Med. Biol. 511 , 75–105 (2002).

Garcia-Falgueras, A. & Swaab, D. F. A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity. Brain 131 , 3115–3117 (2008).

Cohen-Kettenis, P. & Kuiper, B. Transseksualiteit en psychotherapie [Dutch]. Tijdschr. Psychoth. 3 , 153–166 (1984).

Kuiper, B. & Cohen-Kettenis, P. Sex reassignment surgery: a study of 141 Dutch transsexuals. Arch. Sex. Behav. 17 , 439–457 (1988).

Kanhai, R. C., Hage, J. J., Karim, R. B. & Mulder, J. W. Exceptional presenting conditions and outcome of augmentation mammoplasty in male-to female transsexuals. Ann. Plast. Surg. 43 , 476–483 (1999).

Kanagalingm, J. et al . Cricothyroid approximation and subluxation in 21 male-to-female transsexuals. Laryngoscope 115 , 611–618 (2005).

Bouman, M. Laparoscopic assisted colovaginoplasty. Presented at the 2009 biennial World Professional Association for Transgender Health meeting, Oslo.

Rubin, S. O. Sex-reassignment surgery male-to-female. Review, own results and report of a new technique using the glans penis as a pseudoclitoris. Scand. J. Urol. Nephrol. Suppl. 154 , 1–28 (1993).

CAS   PubMed   Google Scholar  

Fang, R. H., Chen, C. F. & Ma, S. A new method for clitoroplasty in male-to-female sex reassignment surgery. Plast. Reconstr. Surg. 89 , 679–682 (1992).

Selvaggi, G. et al . Genital sensitivity in sex reassignment surgery. Ann. Plast. Surg. 58 , 427–433 (2007).

Watanayusakul, S. SRS procedures. The Suporn Clinic [online] , (2010).

Melzer, T. Managing complications of male to female surgery. Presented at the 2007 World Professional Association for Transgender Health biennial meeting, Chicago.

Gilleard, O., Qureshi, M., Thomas, P. & Bellringer, J. Urethral bleeding following male to female gender reassignmetn surgery. Presented at the 2009 World Professional Association for Transgender Health biennial meeting, Oslo.

Beckley, I., Thomas, P. & Bellringer, J. Aetiology and management of recto-vaginal fistulas following male to female gender reassignment. Presented at 2008 EAU section of genitourinary surgeons and the EAU section of andrological urology meeting, Madrid.

Monstrey, S. et al . Chest wall contouring surgery in female-to-male (FTM) transsexuals: a new algorithm. Plast. Reconstr. Surg. 121 , 849–859 (2008).

Mueller, A. & Gooren, L. Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Eur. J. Endocrinol. 159 , 197–202 (2008).

Selvaggi, G., Elander, A. & Branemark, R. Penile epithesis: preliminary study. Plast. Reconstr. Surg. 126 , 265e–266e (2010).

Selvaggi, G. & Elander, A. Penile reconstruction/formation. Curr. Opin. Urol. 18 , 589–597 (2008).

Gilbert, D. A., Jordan, G. H., Devine, C. J. Jr & Winslow, B. H. Microsurgical forearm “cricket bat-transformer” phalloplasty. Plast. Reconstr. Surg. 90 , 711–716 (1992).

Bettocchi, C., Ralph, D. J. & Pryor, J. P. Pedicled pubic phalloplasty in females with gender dysphoria. BJU Int. 95 , 120–124 (2005).

Monstrey, S. et al . Penile reconstruction: is the radial forearm flap really the standard technique? Plast. Reconstr. Surg. 124 , 510–518 (2009).

Selvaggi, G. et al . Donor-site morbidity of the radial forearm free flap after 125 phalloplasties in gender identity disorder. Plast. Reconstr. Surg. 118 , 1171–1177 (2006).

Hoebeke, P. et al . Impact of sex reassignment surgery on lower urinary tract function. Eur. Urol. 47 , 398–402 (2005).

Agrawal, V. & Ralph, D. An audit of implanted penile prosteses in the UK. BJU Int. 98 , 393–395 (2006).

Hoebeke, P. B. et al . Erectile implants in female-to-male transsexuals: our experience in 129 patients. Eur. Urol. 57 , 334–340 (2010).

Vesely, J. et al . New technique of total phalloplasty with reinnervated latissimus dorsi myocutaneous free flap in female-to-male transsexuals. Ann. Plast. Surg. 58 , 544–550 (2007).

Selvaggi, G. et al . Scrotal reconstruction in female-to-male transsexuals: a novel scrotoplasty. Plast. Reconstr. Surg. 123 , 1710–1718 (2009).

Download references

Author information

Authors and affiliations.

Gender Surgery Unit, Charing Cross Hospital, Imperial College NHS Trust, 179–183 Fulham Palace Road, London, W6 8QZ, UK

Gennaro Selvaggi & James Bellringer

You can also search for this author in PubMed   Google Scholar

Contributions

G. Selvaggi and J. Bellringer contributed equally to the research, discussions, writing, reviewing, and editing of this article.

Corresponding author

Correspondence to James Bellringer .

Ethics declarations

Competing interests.

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article.

Selvaggi, G., Bellringer, J. Gender reassignment surgery: an overview. Nat Rev Urol 8 , 274–282 (2011). https://doi.org/10.1038/nrurol.2011.46

Download citation

Published : 12 April 2011

Issue Date : May 2011

DOI : https://doi.org/10.1038/nrurol.2011.46

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

This article is cited by

A bibliometric and visualisation analysis on the research of female genital plastic surgery based on the web of science core collection database.

  • Xianling Zhang

Aesthetic Plastic Surgery (2024)

Chest Feminization in Transwomen with Subfascial Breast Augmentation—Our Technique and Results

  • James Roy Kanjoor
  • Temoor Mohammad Khan

Aesthetic Plastic Surgery (2023)

Vaginoplasty in Male to Female transgenders: single center experience and a narrative review

  • Luca Ongaro
  • Giulio Garaffa
  • Giovanni Liguori

International Journal of Impotence Research (2021)

Urethral complications after gender reassignment surgery: a systematic review

  • L. R. Doumanian

Overview on metoidioplasty: variants of the technique

  • Marta Bizic
  • Borko Stojanovic
  • Miroslav Djordjevic

Quick links

  • Explore articles by subject
  • Guide to authors
  • Editorial policies

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

gender confirmation surgery vs gender reassignment

  • Skip to main content
  • Keyboard shortcuts for audio player

Shots - Health News

  • Your Health
  • Treatments & Tests
  • Health Inc.
  • Public Health

Health Reporting in the States

Bill of the month: a plan for affordable gender-confirmation surgery goes awry.

Emmarie Huetteman

gender confirmation surgery vs gender reassignment

Wren Vetens was promised a significant discount on the cost of her gender-confirmation surgery if she paid in cash upfront, without using her health insurance. Yet afterward, Vetens received an explanation of benefits saying the hospital had billed her insurer nearly $92,000. Lauren Justice for KHN hide caption

Wren Vetens was promised a significant discount on the cost of her gender-confirmation surgery if she paid in cash upfront, without using her health insurance. Yet afterward, Vetens received an explanation of benefits saying the hospital had billed her insurer nearly $92,000.

Wren Vetens thought she'd done everything possible to prepare for her surgery.

She chose a doctoral program in physics at the University of Wisconsin-Madison, a school that not only embraced transgender students like her, but also granted insurance coverage for her gender-confirmation surgery when she enrolled in 2016. When uncertainty over the fate of an Obama-era anti-discrimination rule allowed the state to discontinue such coverage, Vetens and her mother, Kimberly Moreland, an OB-GYN, shopped for another plan.

Deducing the procedure would run from $19,000 to $25,000, based on prices posted online, they purchased insurance from Consolidated Health Plans. It would pay a maximum of $25,000 for the operation.

With that information in hand, Vetens planned ahead: She got her insurer's preapproval and scheduled surgery during winter break of her second year, allowing time for recovery before returning to her studies.

Tell Us Your Billing Story

Do you have a medical bill or explanation of benefits that you'd like us to see? Submit it here and tell us the story behind it .

We may use it, with your permission, in one of our monthly features.

So, she was shocked when a hospital representative called her a couple of months before the long-awaited surgery estimating the bill would be $100,000. That meant she would be on the hook for as much as $75,000 after her insurer's $25,000 payout.

With preparations for the surgery well underway, Vetens was feeling overwhelmed with stress. "There were days when I just couldn't get out of bed for a whole day," she said, describing two weeks of panic attacks.

After mother and daughter complained about the last-minute surprise, a hospital representative offered a solution: If they paid out of pocket and in full before Vetens' surgery — forgoing their use of insurance — the hospital would accept just $20,080, assuring them the hospital would charge nothing to Vetens' insurer. But if they did not decide and pay up right away, the surgery would be canceled.

"I certainly felt that I had no choice," Vetens said.

After Moreland gave the hospital her credit card number for payment, they thought the financial roller coaster was over and Vetens could focus on recovery.

Then the bill came.

Patient: Wren Vetens, then 23, a Ph.D. student at the University of Wisconsin-Madison

Total bill: $91,850.20

Insurance payment: $25,427.91

Vetens owed: $13,191.95 (after $20,080 that was counted as a deposit)

Service provider: University of Wisconsin Hospital in Madison

Medical treatment: Vetens underwent a procedure known as penile inversion vaginoplasty to address her diagnosis of gender dysphoria, a condition resulting from one's sex identified at birth being in conflict with one's gender identity.

The procedure, in which the patient's penile and scrotal tissue is used to create a vagina, generally takes about two to four hours and requires a short inpatient stay, according to Dr. Madeline Deutsch, the medical director for transgender care at the University of California, San Francisco.

Candidates for the procedure must live for at least one year in their identified gender role and undergo at least one year of hormone therapy, Deutsch said. Preparation also includes permanent hair removal.

What gives: Though gender dysphoria is relatively uncommon, many of the billing and insurance issues Vetens encountered are typical for patients planning major surgery. Much of her stress and frustration arose from the vast difference between online price estimates ($19,000-$25,000), the hospital's billed price to the insurer ($91,850) and what it was willing to accept as an upfront cash payment ($20,080).

Hospitals set list prices high because insurers with whom they have contracts typically negotiate them down. In exchange for charging an insurer's members a lower price, doctors and hospitals gain access to those customers, who have incentives to use these in-network providers. Hospitals may offer package deals for procedures to patients, if they pay cash upfront, in part because the hospital avoids the hassle of negotiation.

Officials at University of Wisconsin Hospital said they offered Vetens the option to pay $20,080 for these reasons: to secure extra experience and exposure for the hospital's programs for transgender patients, and to shield Vetens from an even bigger bill. "We were trying to protect the patient," said Dr. Katherine Gast, Vetens' surgeon.

gender confirmation surgery vs gender reassignment

Dr. Kimberly Moreland (left) helped her daughter shop for an insurance plan that would cover Vetens' gender-confirmation surgery. Yet mother and daughter still found themselves caught between the hospital and the insurer. Courtesy of Richard Malatesta/Kimberly Moreland hide caption

Dr. Kimberly Moreland (left) helped her daughter shop for an insurance plan that would cover Vetens' gender-confirmation surgery. Yet mother and daughter still found themselves caught between the hospital and the insurer.

As both parties hedged their bets in trying to determine what a penile inversion vaginoplasty was worth, Vetens was stuck in the middle with the prospect of hugely varying payments.

Lisa Brunette, a hospital spokeswoman, said that, despite having provided Vetens an estimate of $100,000, the hospital really did not know how much it would charge for the procedure because it did not know how much it would be reimbursed by the insurance company. Vetens was the second person to have the procedure at the hospital.

The spokeswoman for the hospital said its contract with Vetens' insurer "relies on a complex formula."

And in an apparent chicken-and-egg quandary, Drew DiGiorgio, president and chief executive of Consolidated Health Plans, said the insurer did not know how much it would reimburse because it did not know how much the hospital would charge.

When Moreland called the hospital to pay the $20,080 price — an option she acknowledged many simply could not afford — she asked for an itemized bill.

The next day, she received a brief letter outlining some of the general services included for the price, such as "physician's fee" and "post surgery labs." Then it simply said: "Penile Inversion Vaginoplasty — $20,080.00."

"How in the world did you come up with a number if you have no idea what it covers?" she asked.

Had Vetens chosen a hospital that did not contract with her insurer, the family could have been reimbursed 60 percent, or about $12,000 of the money paid, since her insurance pays a portion of out-of-network care.

But since Consolidated Health Plans has a contract with the University of Wisconsin Hospital, it said it would not reimburse anything at all. Contracts between insurers and providers discourage such sideline cash transactions, since hospitals can make more money when patients use insurance, as evidenced by Vetens' bill.

Vetens and Moreland appealed to Consolidated Health Plans, feeling that they had been "the victims of a bait-and-switch scam."

The surprises didn't end there. Though multiple hospital representatives reassured Vetens that they wouldn't charge her insurance after her cash payment, Vetens received an explanation of benefits saying the hospital had billed her insurer nearly $92,000.

A hospital bill followed, identifying their $20,080 as "pre-payment," treating it like a partial deposit. Vetens owed more than $13,000, it said.

Studies have shown that more than half of hospital bills contain errors , a problem made worse by the fact that medical bills — with codes and jargon — can be nearly impossible for even savvy patients to understand.

"That was not supposed to happen. That was an error," said Abby Abongwa, a hospital billing official. "That was absolutely an error on our part."

Resolution: After the bill for $91,850 arrived, an alarmed Vetens showed it to her surgeon. The hospital quickly apologized and repaid her insurance company.

Within a few weeks of receiving the appeal — which noted that Vetens and Moreland had contacted a national media outlet — Consolidated Health Plans reimbursed Vetens nearly $18,000, offering her no explanation for why the company had ultimately decided to reverse its earlier judgement that it would not pay anything toward her care.

With their reimbursement, Vetens and Moreland paid about $2,100 for the surgery, all told.

The Takeaway: Be mindful that online pricing estimates frequently represent cash prices, which are often far lower than the price hospitals will bill your insurance.

Ask about a cash price — you may get a better deal. But if you forgo insurance, you're on your own. Your insurer is under no obligation to pay you back for any part of the bill or help you troubleshoot billing, and any payment you make likely will not count toward your deductible.

Enlist your doctor's help. Gast, Vetens' surgeon, proved a powerful advocate for her patient when disputes arose about billing and pricing. Billing representatives might not always be responsive to patients, but it's in the hospital executives' interest to keep staff surgeons happy.

Some of these issues can be settled only through legislation. Right now, there is no legal requirement for hospitals to provide itemized bills to patients. Hospital bills are fraught with errors, and there is little accountability for providers who bill erroneously.

In the meantime, don't be afraid to ask questions and fight back.

Bram Sable-Smith, who contributed to the audio story, is part of NPR's reporting partnership with Side Effects Public Media, member station KBIA and Kaiser Health News.

Kaiser Health News is a nonprofit news service covering health issues. It is an editorially independent program of the Kaiser Family Foundation that is not affiliated with Kaiser Permanente.

You can follow Emmarie Huetteman on Twitter: @emmarieDC .

  • transgender
  • bill of the month
  • gender dysphoria
  • gender identity
  • Health Insurance
  • Plastic surgery
  • BOOK CONSULTATION
  • The Surgical Journey
  • Where do I start?
  • Am I eligible for surgery?
  • Preparing for Surgery
  • General Recovery Info
  • Risks & Safety
  • Top Surgery
  • Top Surgery Techniques
  • Techniques Beyond the Binary
  • Top Surgery Videos
  • Breast Augmentation
  • Facial Surgery
  • Techniques & Incisions
  • Body Contouring
  • Body Feminization
  • Body Masculinization
  • Non-Binary Body Contouring
  • Bottom Surgery
  • “Feminizing” Techniques & Recovery
  • “Masculinizing” Techniques & Recovery
  • Our Services
  • Currently Offered
  • Outside Services
  • Transition 101
  • Introduction to Transitioning
  • Support Services: Helpful Links
  • Transitioning Later In Life
  • Legal Name & Gender Change
  • Transmasculine & Pregnancy
  • Transgender Healthcare
  • Mental Health
  • Hormone Therapy

Trans Youth & Adolescents

  • Mental Health Support
  • Common Questions About Your Child’s Transition
  • For Caregivers
  • Explaining Your Child’s Identity
  • Talking With Schools About Your Child
  • Puberty Blockers
  • Challenging Topics
  • Detransition
  • Adolescents
  • Gatekeeping vs Empowerment
  • Rapid Onset Gender Dysphoria
  • Double Incision
  • Periareolar
  • Inverted T / Aggressive Breast Reduction
  • Gynecomastia
  • Facial Feminization
  • Facial Masculinization
  • Labiaplasty
  • Vaginoplasty
  • Pricing and Financing
  • Insurance Approval
  • Insurance Denial
  • Insurance Accepted
  • Referral Letters
  • Advocacy Team
  • Make a Payment Now
  • Our Philosophy
  • Meet Our Team
  • Office & Facilities
  • Testimonials
  • Get in Touch
  • For Current Patients
  • For Providers

Consultation request

  • Interpretation Services
  • Privacy Policy

telephone

slide toggle Insurance Coverage for Transgender Surgery

  • Top Surgery Costs
  • Facial Surgery Costs
  • MAKE a PAYMENT NOW
  • GCC PHILANTHROPY: GRANT SPONSORSHIP

Do you have any questions? Check our F.A.Q. section or contact us directly!

  • Insurance and Fees

Insurance Coverage for Gender-Affirming Surgery

Medically reviewed by Paul Gonzales on March 13, 2024.

Navigating insurance coverage for gender affirmation surgery can be complex, but many insurance providers now recognize these forms of healthcare for transgender individuals as medically necessary and thereby deserving of coverage. This guide aims to simplify the process of finding and applying for insurance coverage for gender-affirmative surgery, also known as gender confirmation surgery.

The GCC’s list of insurance providers that cover gender-affirming surgeries

Below you can find a list of insurance providers for which our team has successfully obtained approval for top surgery procedures from here. If you don’t see your insurance listed here or are unsure, you can schedule a free, virtual consultation so our team can verify this information for you. Unfortunately, Medicare does not cover any of our procedures at this time.

ACCOLADE

ADVANCE PCS

AETNA

AETNA HMO

AETNA MERITAIN

AETNA MERITAIN (ACCOLADE)

AETNA BETTER HEALTH OF CA MEDI-CAL

ALAMEDA ALLIANCE

ALLEGIANCE

ANTHEM BC

ANTHEM (HMO, EPO)

ANTHEM MEDI-CAL

ANTHEM UCSHIP

ASPIRE HEALTH PLAN (ANTHEM)

BCBS

BCBS FEP

BS CA

BS CA PROMISE HEALTH

BCBS HORIZON (NJ)

BCBS (IL, MA, MI, NC, NM, TX, TN)

BROWN AND TOLLAND (HMO)

CALIFORNIA HEALTH ALLIANCE

CAL OPTIMA MEDI-CAL

CALVIVA HEALTH

CAREFIRST

CIGNA

CHCN

CONTRA COSTA HP

CREDENCE BCBS

EMPIRE BCBS

GEHA (UMR)

GEHA (AETNA)

GEHA (UHC)

HEALTH COMP

HEALTHNET

HEALTHNET UC BLUE AND GOLD (HMO)

HPSM / HPSJ

HIGHMARK

HMSA

HEALTH CARE MANAGEMENT ADMINISTRATORS (HMA)

INDEPENDENCE BC

KEYSTONE FIRST

LA CARE

LIFEWISE

METROPLUS HEALTH

OHIP (ONTARIO HEALTH)

PARTNERSHIP (PHP)

PEBP

PROVIDENCE

PREMERA BCBS

PRESBYTERIAN

PWGA BCBS

REGENCE BCBS

SAN FRANCISCO HEALTH PLAN (MEDI-CAL)

SELECTHEALTH (UHC)

TRINITY HEALTH (AETNA)

UCSHIP BERKELEY

UCHR

UHC

UMR

WELLFLEET BERKELEY

WHA

AETNA BETTER HEALTH – AETB

ALAMEDA ALLIANCE – ALA04

ALLIED BENEFIT SYSTEM – ALL01

ALLIED PHYSICIANS MEDICAL GROUP – ALL09

AMIDA CARE – AMI01

ARIZONA HEALTH CARE COST CONT – AHCCC

BEAVER MEDICAL GROUP – BEA03

BENEFIT ADMINISTRATIVE SYSTEMS – BEN10

BLUE SHIELD PROMISE – BSPROM

BOON CHAPMAN ADMINISTRATORS – BOO01

CAL OPTIMA – CAL01

CALIFORNIA BLUE SHIELD – CAL02

CALIFORNIA HEALTH AND WELLNESS – CAHW

CALIFORNIA MEDICAL – CAL03

CENCAL HEALTH – CENCA

CENTRAL COAST ALLIANCE FOR HEALTH – CEN05

CHCN – CHCN

CHILDRENS FIRST MEDICAL GROUP – CHI03

CIGNA PPO – CIG09

CONTRA COSTA HEALTH PLAN – CCHP

EXCLUSIVE SURGERY SOLUTIONS – ESURG

FACEY MEDICAL FOUNDATION – FACEY

FIRST CHOICE HEALTH NETWORK – FIR12

FIRST CHOICE MEDICAL GROUP – FIR01

GOLD COAST HEALTH PLAN – GOL03

HEALTH NET CC – HNCC

HEALTH NET MCAL – HNMC

HEALTH PARTNERS – HEA81

HEALTH PLAN OF SAN JOAQUIN – HEA50

HEALTH PLAN OF SAN MATEO – HEA57

HEALTH PLANS – HEA18

HEALTHCARE PARTNERS – HEA60

HEALTHSCOPE BENEFITS – HEA90

HILL PHYSICIANS MEDICAL GROUP – HIL01

HOMETOWN HEALTH – HOME1

INLAND EMPIRE HEALTH PLAN – INL01

LA CARE HEALTH PLAN – LAC02

LASALLE MEDICAL ASSOCIATES – LAS01

LIFEWISE – LIFE01

MEDICA – MEDICA

MODA HEALTH PLAN – MODA

MOLINA HEALTHCARE – MOL02

MOLINA HEALTHCARE OF CALIFORNIA – MOL01

OSCAR – OSCAR

PACIFIC SOURCE COMMUNITY SOLUTIONS – PAC06

PACIFIC SOURCE HEALTH PLANS – PAC07

PARTNERSHIP HEALTH PLAN – PAR05

PRESBYTERIAN HEALTH PLAN – PRE23

PRIORITY HEALTH OF MICHIGAN – PRI20

PROVIDENCE HEALTH PLAN – PRO15

RIVER CITY MEDICAL GROUP – RCMG

SAN FRANCISCO HEALTH PLAN – SFHP

SANTA CLARA FAMILY HEALTH PLAN – SAN04

SANTE COMMUNITY PHYSICIANS – SAN02

SELECTHEALTH – SEL10

SHARP HEALTH PLAN – SHAR1

TRUSTMARK HEALTH BENEFITS – TRU01

TUFTS HEALTH PLANS – TUF01

UC DAVIS – UCDAV

UHC COMMUNITY PLAN OF NY – UHCCP

US NETWORKS AND ADMIN SVCS – USN01

VALLEY HEALTH PLAN – VAL05

VANTAGE MEDICAL GROUP – VAN04

*  This list may be subject to change and does not guarantee insurance coverage for top surgery. Successful approvals may vary based on several factors, such as the type of plan for each insurance company.

How to Get Coverage: An Overview

The following information is meant to give you an overview of all the components you will need to take into consideration in finding an insurance plan that will cover your gender-affirming surgery.

  • Contact your insurance provider directly to inquire about coverage for gender reassignment surgery. You can start by calling the phone number on your insurance card.
  • Review your insurance policy or member handbook carefully for any exclusions or limitations related to transgender healthcare.
  • Consult the Transgender Legal Defense & Education Fund (TLDEF) for a list of insurance companies known to offer coverage for gender affirmation procedures.
  • Coverage Exclusions: Federal and state laws prohibit discrimination against transgender individuals by most public and private insurance health plans. This means insurance companies must cover transition-related care that’s medically necessary and it is illegal for them to deny coverage, in most cases. Some plans may still have exclusions in their policies, but you can ask for an exception or request the removal of the exclusion.
  • Medical Necessity: Virtually all major insurance companies now recognize that gender-affirming medical care for transgender patients is medically necessary. However, the specifics of what procedures or treatments are covered will depend on each insurance plan. Most of them will require letters from healthcare providers to support medical necessity. You can find a list of therapists that can provide support letters for insurance coverage through GALAP .
  • Referral Letters: To secure insurance coverage, patients will need 1-2 letters from healthcare providers. Besides a therapist support letter, if GCC surgeons are not in-network providers, you will need a referral letter from your Primary Care Physician.
  • Financial Options: If your insurance provider does not cover gender-affirming surgery, other options include paying out-of-pocket, taking out a personal loan, or seeking financial help from charities and organizations.

Identifying Insurance Providers That Cover Gender Affirming Surgery

If you live in the United States, here’s a list of resources to help you identify insurance providers offering coverage for gender-affirming surgery:

  • Transgender Legal Defense & Education Fund (TLDEF) provides a list of insurance companies that have coverage for gender-affirming care.
  • Campus Pride provides a list of colleges and universities by state that cover gender-affirming surgery or hormone therapy under student health insurance.
  • Our Insurance Advocacy Team here at the Gender Confirmation Center has successfully secured coverage for surgery from the insurance companies mentioned above.

Navigating Insurance Policies for Gender Affirming Surgery

The National Center for Transgender Equality created a guide to help navigate getting your insurance to cover gender-affirming care. This process can be summarized in 3 steps below:

  • Learn what your insurance plan covers for gender-affirming care by calling your insurance company and ask what medical policies on gender dysphoria treatment are applicable to your plan. You may also find this information in the Member Handbook provided by your insurance.
  • Determine the type of insurance you have (self-funded vs fully insured) to see if there are exclusions or limitations on healthcare coverage for transition-related care. Self-funded plans (e.g. insurance through work, school, or government employment) typically have exclusions or limitations to coverage that may be exempt from state protection laws. You may need to request your employer or school to remove the exclusion before insurance can cover surgery.
  • Gather necessary documentation , such as letters from healthcare providers (i.e. mental health provider). Most insurance companies require at least 2 letters to cover bottom surgery procedures. In this case, a t least one should come from a licensed mental health professional. The second can come from a mental health or a healthcare provider: for example, an endocrinologist or primary care provider who has been involved in your hormone therapy.  We recognize that the two-letter insurance requirement can be an extra barrier for patients to access medically necessary, gender-affirming care. For this reason, once you have requested a surgical consultation , we can help you through securing this and any other documentation.
  • Submit a pre-authorization request to your insurance provider by writing a letter to explain why the procedure is necessary and why refusing to provide coverage may be illegal.
  • Follow up with your insurance to ensure the request is being processed or check on its status. Your insurance will send you a notification if your request has been approved or denied.

Navigating this process can be challenging but our Insurance Advocacy team works directly with your insurance for each step of this process until the insurance company reaches a decision for the preauthorization request. This service is provided free of charge for our patients to ensure the best chance of success in getting their surgery covered.

Overcoming Challenges in Insurance Coverage for Gender Affirming Surgery

  • Denial of preauthorization request or claim for reimbursement: Understanding the reason for denial can help determine your options for appealing this decision. Seeking legal assistance from a lawyer may help facilitate this process.
  • Dealing with out-of-network coverage: Insurance companies usually have a list of “in-network” healthcare providers that are covered by a particular plan. While some patients are restricted to these in-network providers (i.e. HMO plans), others may have the option to see out-of-network providers if the in-network options are not qualified (i.e., PPO plans). For example, your insurance may restrict you to seek care from a surgeon who can perform mastectomies but may not have training in gender-affirming techniques. In such cases, you have the right to seek out an out-of-network provider who is qualified in gender-affirming surgery, as the in-network provider cannot fulfill your specific needs. It’s essential to understand that the insurance may initially refuse coverage for out-of-network surgeons or facilities, but this decision can be challenged through the appeals process.
  • Consider an independent review for denials : If the insurance company continues to deny coverage, you may have the option to request an independent review by a third-party organization. This review can provide an unbiased evaluation of your case and potentially overturn the denial.

For Patients Interested in Body Contouring

Exploring financial aid options for gender affirming surgery.

  • Surgery Grants: Organizations and programs may offer grants or financial aid to help cover the costs of surgery. The GCC works with various organizations to help with costs of surgery. Learn more about them here.
  • CareCredit: GCC has partnered with CareCredit to help patients finance the costs of surgery. Patients can apply for this credit card to see if they qualify and figure out what payment plan options are available.

Advocating for Comprehensive Insurance Coverage

The Affordable Care Act prohibits discrimination based on gender identity, which can be leveraged when seeking coverage for gender-affirming surgery. Despite this, many still face challenges with access or coverage of medically necessary transition related care. Recently, these states have limited protections for transgender youth after passing laws banning their access to gender-affirming care.

Navigating insurance coverage for gender-affirming surgery can be challenging, but our Insurance Advocacy team is dedicated to ensuring access to care for our patients. The National Center for Transgender Equality and Transgender Legal Defense and Education Fund also provides a comprehensive list of resources to help patients find and get insurance coverage for gender-affirming care.

Request a Free Surgical Consultation Today.

All virtual and in-person consultations with our board-certified surgeons are free. Once you fill out this form, our patient care team will reach out and guide you through every step to get to surgery.

gender confirmation surgery vs gender reassignment

Suite 1010, 450 Sutter St San Francisco, CA 94108 Phone: (415) 780-1515 Fax: ( 628) 867-6510

Gender Journey Resources

  • Trans Youth & Adolescents

Before & After

  • Top surgery
  • Virtual Consultations

Board Certification & Memberships

gender confirmation surgery vs gender reassignment

  • Terms of Use

Copyright © 2023 Gender Confirmation Center. All Rights Reserved.

FACT CHECK: Is The Rate Of Regret After Gender-Affirming Surgery Only 1%?

A post shared on social media  claims only 1% of people regret their gender-affirmation surgery.

  View this post on Instagram   A post shared by matt bernstein (@mattxiv)

Verdict: Misleading

While the study cited does find a 1% regret rate, it and other subsequent studies share disclaimers and the limitations of research, suggesting the rate may actually be higher.

Fact Check:

The Instagram post claims that only 1% of patients regret their gender transition surgeries. The source used is “Regret after Gender-affirmation Surgery: A systematic Review and Meta-analysis of Prevalence” from the National Library of Medicine (NLM).

The caption is misleading, due to several factors and lack of research that were identified by the study itself and other subsequent papers. (RELATED: Did Canada Release A New Passport That Features Pride Flags?)

This study did not conduct original research, but rather compiled research done in many different places which resulted in a disclaimer warning of the danger of generalizing the results. “There is high subjectivity in the assessment of regret and lack of standardized questionnaires,” which varies from study to study, according to the NLM document.

The study quotes a 2017 study published in the Journal of Sex and Marital Therapy , which conducted a follow-up survey of regret among patients after their transition. The study notes a major limitation was that few patients followed up after surgery.

“This study’s main limitation was the sample representativeness. With a response rate of 37%, similar to the attrition rates of most follow-up studies,” according to the study. Out of the response rate, six percent reported dissatisfaction or regret with the surgery, the study claims.

Additional data found in a Cambridge University Press study showed subjects on average do not express regret in the transition until an average of 10 years after their surgery. The study also claimed twelve cases out of the 175 selected, or around seven percent, had expressed detransitioning.

“There is some evidence that people detransition on average 4 or 8 years after completion of transition, with regret expressed after 10 years,” the study suggests. It also states that the actual rate is unknown, with some ranging up to eight percent.

Another study published in 2007 from Sweden titled, “ Factors predictive of regret in sex reassignment ,” found that around four percent of patients who underwent sex reassignment surgery between 1972-1992 regretted the measures taken. The research was done over 10 years after the the procedures.

The National Library of Medicine study only includes individuals who underwent transition surgery and does not take into account regret rates among individuals who took hormone replacement. Research from The Journal of Clinical Endocrinology and Metabolism (JCEM) found that the hormone continuation rate was 70 percent, suggesting nearly 30 percent discontinued their hormone treatment for a variety of reasons.

“In the largest surgery study, approximately 1% of patients regretted having gender-confirmation surgery,” Christina Roberts, M.D, a professor of Pediatrics at the University of Missouri-Kansas City School of Medicine and a participant for the study for the JCEM, told Check Your Fact via email.

Roberts stated that while there were multiple major factors in regards to those regretting the surgery, including poor cosmetic outcome and lack of social support, she claimed discontinuation of hormone therapies and other treatment are “not the same thing as regret.”

“This is an apples to oranges comparison,” Roberts added. (RELATED: Is Disney World Replacing The American Flag With The LGBTQ+ Pride Flag In June 2023?)

Check Your Fact reached out to multiple doctors and researchers associated with the above and other studies and will update this piece if responses are provided.

Joseph Casieri

Fact check reporter.

gender confirmation surgery vs gender reassignment

  • Skip to Nav
  • Skip to Main
  • Skip to Footer
  • Saved Articles
  • Newsletters

Health Insurers Hit With CA's Largest-Ever Penalty Over Gender-Affirming Care Denials

Please try again

gender confirmation surgery vs gender reassignment

Two major California health insurers were hit with the state’s largest-ever fines for illegally denying coverage for gender-affirming care in a case that will compel them to revise how they treat patients diagnosed with gender dysphoria.

The $850,000 combined penalties against  Blue Cross of California Partnership Plan  and its  Anthem Blue Cross  also require the insurers to hire a dedicated case manager for people with gender dysphoria. Over 150 individuals who were denied coverage for such procedures will see their cases reviewed, and most have already seen reversals, according to the decision.

The insurers comply with the decision of the Department of Managed Health Care, a state office that regulates their industry.

“We take these matters seriously and have worked directly with the Department of Managed Health Care to identify and implement specific corrective actions to address and resolve the identified matters,” wrote Mike Bowman, a spokesperson for the insurance providers, in a statement to CalMatters.

From 2017 to 2020, two California plans by  Anthem Blue Cross and its state partnership  categorized over 20 surgeries, such as facial implants, hair removal, voice therapy and breast augmentation, as “not medically necessary.” But the procedures were covered if they  corrected “abnormal” body structures to create a “normal appearance” for “the target gender.”

The language the company employed “could create confusion for the reviewers regarding the medical necessity of the 22 procedures,” wrote Sonia R. Fernandes, deputy director and chief counsel office of enforcement at the Department of Managed Healthcare in an Aug. 15 ruling  against ​​the Blue Cross of California Partnership Plan.

In a parallel ruling against Anthem Blue Cross, she wrote that the company “did not provide alternate criteria” to help clinics and hospitals understand when the procedures would qualify for coverage. The plan in question called the procedures “cosmetic” when used to “improve the gender-specific appearance of an individual who has undergone, or is planning to undergo sex reassignment surgery.”

The contested plans were in place years after the state implemented the  Insurance Gender Nondiscrimination Act in 2013 , which included many LGBTQ+ Californians into anti-discrimination protections for health coverage. Blue Cross officials acknowledged to regulators that the plans did not comply with state law, but the company and its affiliates have faced growing criticism in the past year over its handling of gender-affirming care.

It’s not the first time California’s insurance regulators have cracked down on such forms of discrimination. The department in 2017 issued a $200,000 fine against the insurer Health Net for  gaps in coverage related to gender reassignment surgery  and other procedures.

Most recently, in December, the Department of Managed Health Care  announced a $200,000 fine  against  California Physicians’ Service , the doctor reimbursement side of BlueCross, also known as Blue Shield of California.

That  decision centered around an individual who was diagnosed with gender dysphoria and received prior-approved services from an out-of-network provider but later saw their health care coverage suspended. The fine has since been paid, and the company has taken corrective action as requested by the state.

In this month’s case, regulators said the insurance companies must also provide written confirmation that they have modified their rules, ensured further denials comply with state law and provided training to the doctors and health care administrators.

Supported by the California Health Care Foundation (CHCF), which works to ensure that people have access to the care they need, when they need it, at a price they can afford. Visit www.chcf.org to learn more.

To learn more about how we use your information, please read our privacy policy.

Information

  • Author Services

Initiatives

You are accessing a machine-readable page. In order to be human-readable, please install an RSS reader.

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess .

Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.

Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive positive feedback from the reviewers.

Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.

Original Submission Date Received: .

  • Active Journals
  • Find a Journal
  • Proceedings Series
  • For Authors
  • For Reviewers
  • For Editors
  • For Librarians
  • For Publishers
  • For Societies
  • For Conference Organizers
  • Open Access Policy
  • Institutional Open Access Program
  • Special Issues Guidelines
  • Editorial Process
  • Research and Publication Ethics
  • Article Processing Charges
  • Testimonials
  • Preprints.org
  • SciProfiles
  • Encyclopedia

jcm-logo

Article Menu

gender confirmation surgery vs gender reassignment

  • Subscribe SciFeed
  • Recommended Articles
  • Google Scholar
  • on Google Scholar
  • Table of Contents

Find support for a specific problem in the support section of our website.

Please let us know what you think of our products and services.

Visit our dedicated information section to learn more about MDPI.

JSmol Viewer

Gender reassignment and the role of the laboratory in monitoring gender-affirming hormone therapy.

gender confirmation surgery vs gender reassignment

1. Introduction

3. gender development, genesis of gender incongruence, 4. guidelines for gaht, 4.1. adolescent gi, 4.2. adult gi, 5. laboratory tests in transgender afab/amab individuals, 5.1. red blood cell indices, 5.2. renal function, 5.3. liver enzymes, 5.4. lipids, 5.5. cardiac biomarkers, 5.6. reproductive hormones, 5.7. ferritin, 5.8. prostate specific antigen.

Laboratory Tests CommentsReference
Estradiol treatmentTestosterone treatmentEstradiol GAHT shifts haemoglobin, haematocrit to lower values in line with cisgender women’s reference intervals. Testosterone GAHTshifts reference intervals to higher levels in line with cisgender men’s reference intervals[ ]
RBCDecreaseIncrease
HemoglobinDecreaseIncrease
HematocritDecreaseIncrease
CreatinineDecreaseIncreaseThe most reno protective calculated GFR either male/female is suggested; 24h creatinine clearance if indicated[ ]
High sensitivity troponin I Report a reference range that would allow critical results to be appropriately followed; an approach of least harm to the patient is suggested[ ]
Ferritin Laboratories use dual reference ranges for cisgender individuals. Interpretation is based on clinical presentation (e.g., pregnancy) in combination with full blood count, liver function test, and markers of inflammation, e.g., CRP.
Iron overload: If secondary causes excluded, investigation for primary haemochromatosis gene may be indicated
[ ]
Reproductive hormonesTestosterone, Estradiol Following stabilisation of treatment with gender-affirming hormones, guidelines suggest treatment goals are physiological levels of the affirmed gender identity cisgender adults.
The time of measurement of the hormone is dependent on the method of administration as well as formulation of the GAHT
[ ]
Reproductive hormones LH, FSH, AMH, and DHEAS are variable in a transgender population and are interpreted with clinical information[ , ]
PSA Data for reference ranges in transgender AMAB people and from screening for prostatic cancer is not available[ ]
Renal function/liver function/lipid profile Guidelines suggest monitoring of liver function/renal function and lipids during GAHT treatment. Sex-specific reference ranges are not ordinarily stated for the measurements[ ]

5.9. Laboratory Test Reference Intervals for Transgender Population

6. electronic medical record systems (emr), 7. gaht and other laboratory markers, 7.1. risk of venous thromboembolism in amab people, 7.2. hyperprolactinemia, 7.3. other sex hormone dependent tumours, 7.4. bone mineral density, 8. gaht, vascular health and cardiovascular disease, and impact of aging in transgender adults, 9. conclusions, 10. future directions, conflicts of interest.

  • Glintborg, D.; T’Sjoen, G.; Ravn, P.; Andersen, M.S. Management of endocrine disease: Optimal feminizing hormone treatment in transgender people. Eur. J. Endocrinol. 2021 , 185 , R49–R63. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Hembree, W.C.; Cohen-Kettenis, P.T.; Gooren, L.; Hannema, S.E.; Meyer, W.J.; Murad, M.H.; Rosenthal, S.M.; Safer, J.D.; Tangpricha, V.; T’Sjoen, G.G. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2017 , 102 , 3869–3903, Erratum in J. Clin. Endocrinol. Metab. 2018 , 103 , 699. Erratum in J. Clin. Endocrinol. Metab. 2018 , 103 , 2758–2759. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Coleman, E.; Radix, A.E.; Bouman, W.P.; Brown, G.R.; de Vries, A.L.C.; Deutsch, M.B.; Ettner, R.; Fraser, L.; Goodman, M.; Green, J.; et al. Standards of Care for the Health of Transgender and Gender Diverse People, Version 8. Int. J. Transgender Health. 2022 , 23 (Suppl. 1), S1–S259. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Available online: https://auspath.org.au/wp-content/uploads/2022/05/AusPATH_Informed-Consent-Guidelines_DIGITAL.pdf (accessed on 2 June 2024).
  • Cheung, A.S.; Wynne, K.; Erasmus, J.; Murray, S.; Zajac, J.D. Position statement on the hormonal management of adult transgender and gender diverse individuals. Med. J. Aust. 2019 , 211 , 127–133. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Beek, F.T.; Cohen-Kettenis, P.T.; Kreukels, B.P.C. Gender incongruence/gender dysphoria and its classification history. Int. Rev. Psychiatry 2016 , 28 , 5–12. [ Google Scholar ] [ CrossRef ]
  • Reyes, A.P.; León, N.Y.; Frost, E.R.; Harley, V.R. Genetic control of typical and atypical sex development. Nat. Rev. Urol. 2023 , 20 , 434–451. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Richardson, B.E.; Lehmann, R. Mechanisms guiding primordial germ cell migration: Strategies from different organisms. Nat. Rev. Mol. Cell Biol. 2010 , 11 , 37–49. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Ostrer, H.; Huang, H.Y.; Masch, R.J.; Shapiro, E. A cellular study of human testis development. Sex. Dev. 2007 , 1 , 286–292. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • She, Z.Y.; Yang, W.X. Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development? Semin. Cell Dev. Biol. 2017 , 63 , 13–22. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Edelsztein, N.Y.; Valeri, C.; Lovaisa, M.M.; Schteingart, H.F.; Rey, R.A. AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications. Front. Endocrinol. 2022 , 13 , 906381. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Rey, R.A.; Grinspon, R.P. Normal male sexual differentiation and aetiology of disorders of sex development. Best. Pract. Res. Clin. Endocrinol. Metab. 2011 , 25 , 221–238. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Emmanuel, M.; Bokor, B.R. Tanner Stages. [Updated 11 December 2022]. In StatPearls [Internet] ; StatPearls Publishing: Treasure Island, FL, USA, 2024. Available online: https://www.ncbi.nlm.nih.gov/books/NBK470280/ (accessed on 25 August 2024).
  • Eliot, L.; Ahmed, A.; Khan, H.; Patel, J. Dump the “dimorphism”: Comprehensive synthesis of human brain studies reveals few male-female differences beyond size. Neurosci. Biobehav. Rev. 2021 , 125 , 667–697. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Ruigrok, A.N.; Salimi-Khorshidi, G.; Lai, M.C.; Baron-Cohen, S.; Lombardo, M.V.; Tait, R.J.; Suckling, J. A meta-analysis of sex differences in human brain structure. Neurosci. Biobehav. Rev. 2014 , 39 , 34–50. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Lafta, M.S.; Mwinyi, J.; Affatato, O.; Rukh, G.; Dang, J.; Andersson, G.; Schiöth, H.B. Exploring sex differences: Insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology. Front. Neurosci. 2024 , 18 , 1340108. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Fine, R.D.; Olson, K.R.; Gülgöz, S.; Horton, R.; Gelman, S.A. Gender Essentialism Predicts Prejudice against Gender Nonconformity in Two Cultural Contexts. Soc. Dev. 2024 , 33 , e12720. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Mueller, S.C.; Guillamon, A.; Zubiaurre-Elorza, L.; Junque, C.; Gomez-Gil, E.; Uribe, C.; Khorashad, B.S.; Khazai, B.; Talaei, A.; Habel, U.; et al. The Neuroanatomy of Transgender Identity: Mega-Analytic Findings From the ENIGMA Transgender Persons Working Group. J. Sex. Med. 2021 , 18 , 1122–1129. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Saraswat, A.; Weinand, J.D.; Safer, J.D. Evidence supporting the biologic nature of gender identity. Endocr. Pract. 2015 , 21 , 199–204. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Foreman, M.; Hare, L.; York, K.; Balakrishnan, K.; Sánchez, F.J.; Harte, F.; Erasmus, J.; Vilain, E.; Harley, V.R. Genetic Link Between Gender Dysphoria and Sex Hormone Signaling. J. Clin. Endocrinol. Metab. 2019 , 104 , 390–396, Erratum in J. Clin. Endocrinol. Metab. 2020 , 105 , 393. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Fernández, R.; Guillamon, A.; Cortés-Cortés, J.; Gómez-Gil, E.; Jácome, A.; Esteva, I.; Almaraz, M.; Mora, M.; Aranda, G.; Pásaro, E. Molecular basis of Gender Dysphoria: Androgen and estrogen receptor interaction. Psychoneuroendocrinology 2018 , 98 , 161–167. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Steensma, T.D.; Kreukels, B.P.; de Vries, A.L.; Cohen-Kettenis, P.T. Gender identity development in adolescence. Horm. Behav. 2013 , 64 , 288–297. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Zhang, Q.; Goodman, M.; Adams, N.; Corneil, T.; Hashemi, L.; Kreukels, B.; Motmans, J.; Snyder, R.; Coleman, E. Epidemiological considerations in transgender health: A systematic review with focus on higher quality data. Int. J. Transgender Health. 2020 , 21 , 125–137. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Brierley, J.; Larcher, V.; Hadjipanayis, A.A.; Grossman, Z. European Academy of Paediatrics statement on the clinical management of children and adolescents with gender dysphoria. Front. Pediatr. 2024 , 12 , 1298884. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Claahsen-van der Grinten, H.; Verhaak, C.; Steensma, T.; Middelberg, T.; Roeffen, J.; Klink, D. Gender incongruence and gender dysphoria in childhood and adolescence-current insights in diagnostics, management, and follow-up. Eur. J. Pediatr. 2021 , 180 , 1349–1357. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Brik, T.; Vrouenraets, L.J.J.J.; de Vries, M.C.; Hannema, S.E. Trajectories of Adolescents Treated with Gonadotropin-Releasing Hormone Analogues for Gender Dysphoria. Arch. Sex. Behav. 2020 , 49 , 2611–2618. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Steininger, J.; Knaus, S.; Kaufmann, U.; Ott, J.; Riedl, S. Treatment trajectories of gender incongruent Austrian youth seeking gender-affirming hormone therapy. Front. Endocrinol. 2024 , 15 , 1258495. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Panagiotakopoulos, L. Transgender medicine—Puberty suppression. Rev. Endocr. Metab. Disord. 2018 , 19 , 221–225. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Halasz, G.; Amos, A. Gender dysphoria: Reconsidering ethical and iatrogenic factors in clinical practice. Australas. Psychiatry 2024 , 32 , 26–31. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Calcaterra, V.; Tornese, G.; Zuccotti, G.; Staiano, A.; Cherubini, V.; Gaudino, R.; Fazzi, E.M.; Barbi, E.; Chiarelli, F.; Corsello, G.; et al. Adolescent gender dysphoria management: Position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry. Ital. J. Pediatr. 2024 , 50 , 73. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Dahlen, S.; Connolly, D.; Arif, I.; Junejo, M.H.; Bewley, S.; Meads, C. International clinical practice guidelines for gender minority/trans people: Systematic review and quality assessment. BMJ Open 2021 , 11 , e048943. [ Google Scholar ] [ CrossRef ]
  • Humble, R.M.; Imborek, K.L.; Nisly, N.; Greene, D.N.; Krasowski, M.D. Common Hormone Therapies Used to Care for Transgender Patients Influence Laboratory Results. J. Appl. Lab. Med. 2019 , 3 , 799–814. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • SoRelle, J.A.; Jiao, R.; Gao, E.; Veazey, J.; Frame, I.; Quinn, A.M.; Day, P.; Pagels, P.; Gimpel, N.; Patel, K. Impact of Hormone Therapy on Laboratory Values in Transgender Patients. Clin. Chem. 2019 , 65 , 170–179. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Allen, A.N.; Jiao, R.; Day, P.; Pagels, P.; Gimpel, N.; SoRelle, J.A. Dynamic Impact of Hormone Therapy on Laboratory Values in Transgender Patients over Time. J. Appl. Lab. Med. 2021 , 6 , 27–40. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Millington, K.; Lee, J.Y.; Olson-Kennedy, J.; Garofalo, R.; Rosenthal, S.M.; Chan, Y.M. Laboratory Changes During Gender-Affirming Hormone Therapy in Transgender Adolescents. Pediatrics 2024 , 153 , e2023064380. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Murphy, W.G. The sex difference in haemoglobin levels in adults—Mechanisms, causes, and consequences. Blood Rev. 2014 , 28 , 41–47. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Greene, D.N.; McPherson, G.W.; Rongitsch, J.; Imborek, K.L.; Schmidt, R.L.; Humble, R.M.; Nisly, N.; Dole, N.J.; Dane, S.K.; Frerichs, J.; et al. Hematology reference intervals for transgender adults on stable hormone therapy. Clin. Chim. Acta. 2019 , 492 , 84–90. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Humble, R.M.; Greene, D.N.; Schmidt, R.L.; Winston McPherson, G.; Rongitsch, J.; Imborek, K.L.; Nisly, N.; Dole, N.J.; Dane, S.K.; Frerichs, J.; et al. Reference Intervals for Clinical Chemistry Analytes for Transgender Men and Women on Stable Hormone Therapy. J. Appl. Lab. Med. 2022 , 7 , 1131–1144. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Hashemi, L.; Zhang, Q.; Getahun, D.; Jasuja, G.K.; McCracken, C.; Pisegna, J.; Roblin, D.; Silverberg, M.J.; Tangpricha, V.; Vupputuri, S.; et al. Longitudinal Changes in Liver Enzyme Levels Among Transgender People Receiving Gender Affirming Hormone Therapy. J. Sex. Med. 2021 , 18 , 1662–1675. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Krasowski, M.D.; Hines, N.G.; Imborek, K.L.; Greene, D.N. Impact of sex used for assignment of reference intervals in a population of patients taking gender-affirming hormones. J. Clin. Transl. Endocrinol. 2024 , 36 , 100350. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Wierckx, K.; Van Caenegem, E.; Schreiner, T.; Haraldsen, I.; Fisher, A.D.; Toye, K.; Kaufman, J.M.; T’Sjoen, G. Cross-sex hormone therapy in trans persons is safe and effective at short-time follow-up: Results from the European network for the investigation of gender incongruence. J. Sex. Med. 2014 , 11 , 1999–2011. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Deutsch, M.B.; Bhakri, V.; Kubicek, K. Effects of cross-sex hormone treatment on transgender women and men. Obstet. Gynecol. 2015 , 125 , 605–610. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Fernandez, J.D.; Tannock, L.R. Metabolic effects of hormone therapy in transgender patients. Endocr. Pract. 2016 , 22 , 383–388. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Waters, J.; Linsenmeyer, W. The impact of gender-affirming hormone therapy on nutrition-relevant biochemical measures. Front. Nutr. 2024 , 11 , 1339311. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Greene, D.N.; Schmidt, R.L.; Christenson, R.H.; Rongitsch, J.; Imborek, K.L.; Rebuck, H.; Lorey, T.S.; Saenger, A.K.; Krasowski, M.D. Distribution of High-Sensitivity Cardiac Troponin and N-Terminal Pro-Brain Natriuretic Peptide in Healthy Transgender People. JAMA Cardiol. 2022 , 7 , 1170–1174. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Wang, J.; Taur, A.; Chen, A.; Wu, Y.L.; Lee, M.S. Sex-Specific Cardiac Troponin Thresholds in Transgender Patients With Suspected Acute Coronary Syndrome. JAMA Netw. Open. 2023 , 6 , e2337345. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Greene, D.N.; Schmidt, R.L.; Winston McPherson, G.; Rongitsch, J.; Imborek, K.L.; Dickerson, J.A.; Drees, J.C.; Humble, R.M.; Nisly, N.; Dole, N.J.; et al. Reproductive Endocrinology Reference Intervals for Transgender Women on Stable Hormone Therapy. J. Appl. Lab. Med. 2021 , 6 , 15–26. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Greene, D.N.; Schmidt, R.L.; Winston-McPherson, G.; Rongitsch, J.; Imborek, K.L.; Dickerson, J.A.; Drees, J.C.; Humble, R.M.; Nisly, N.; Dole, N.J.; et al. Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy. J. Appl. Lab. Med. 2021 , 6 , 41–50. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • McKinnon, E.J.; Rossi, E.; Beilby, J.P.; Trinder, D.; Olynyk, J.K. Factors that affect serum levels of ferritin in Australian adults and implications for follow-up. Clin. Gastroenterol. Hepatol. 2014 , 12 , 101–108.e4. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • de Nie, I.; de Blok, C.J.M.; van der Sluis, T.M.; Barbé, E.; Pigot, G.L.S.; Wiepjes, C.M.; Nota, N.M.; van Mello, N.M.; Valkenburg, N.E.; Huirne, J.; et al. Prostate Cancer Incidence under Androgen Deprivation: Nationwide Cohort Study in Trans Women Receiving Hormone Treatment. J. Clin. Endocrinol. Metab. 2020 , 105 , e3293–e3299. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Loria, M.; Gilbert, D.; Tabernacki, T.; Maravillas, M.A.; McNamara, M.; Gupta, S.; Mishra, K. Incidence of prostate cancer in transgender women in the US: A large database analysis. Prostate Cancer Prostatic Dis. 2024; Epub ahead of print . [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Crowley, F.; Mihalopoulos, M.; Gaglani, S.; Tewari, A.K.; Tsao, C.K.; Djordjevic, M.; Kyprianou, N.; Purohit, R.S.; Lundon, D.J. Prostate cancer in transgender women: Considerations for screening, diagnosis and management. Br. J. Cancer. 2023 , 128 , 177–189. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Irwig, M.S. Which reference range should we use for transgender and gender diverse patients? J. Clin. Endocrinol. Metab. 2021 , 106 , e1479–e1480. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Cheung, A.S.; Lim, H.Y.; Cook, T.; Zwickl, S.; Ginger, A.; Chiang, C.; Zajac, J.D. Approach to Interpreting Common Laboratory Pathology Tests in Transgender Individuals. J. Clin. Endocrinol. Metab. 2021 , 106 , 893–901. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Cahill, S.R.; Baker, K.; Deutsch, M.B.; Keatley, J.; Makadon, H.J. Inclusion of Sexual Orientation and Gender Identity in Stage 3 Meaningful Use Guidelines: A Huge Step Forward for LGBT Health. LGBT Health 2016 , 3 , 100–102. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Patel, K.; Lyon, M.E.; Luu, H.S. Providing Inclusive Care for Transgender Patients: Capturing Sex and Gender in the Electronic Medical Record. J. Appl. Lab. Med. 2021 , 6 , 210–218. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Totaro, M.; Palazzi, S.; Castellini, C.; Parisi, A.; D’Amato, F.; Tienforti, D.; Baroni, M.G.; Francavilla, S.; Barbonetti, A. Risk of Venous Thromboembolism in Transgender People Undergoing Hormone Feminizing Therapy: A Prevalence Meta-Analysis and Meta-Regression Study. Front. Endocrinol. 2021 , 12 , 741866. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Ott, J.; Kaufmann, U.; Bentz, E.K.; Huber, J.C.; Tempfer, C.B. Incidence of thrombophilia and venous thrombosis in transsexuals under cross-sex hormone therapy. Fertil. Steril. 2010 , 93 , 1267–1272. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Dix, C.; Moloney, M.; Tran, H.A.; McFadyen, J.D. Venous Thromboembolism and Estrogen-Containing Gender-Affirming Hormone Therapy. Thromb. Haemost. 2024 , 124 , 387–398. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Wilson, L.M.; Baker, K.E.; Sharma, R.; Dukhanin, V.; McArthur, K.; Robinson, K.A. Effects of antiandrogens on prolactin levels among transgender women on estrogen therapy: A systematic review. Int. J. Transgender Health 2020 , 21 , 391–402. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Wahlström, E.; Audisio, R.A.; Selvaggi, G. Aspects to consider regarding breast cancer risk in trans men: A systematic review and risk management approach. PLoS ONE 2024 , 19 , e0299333. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Pamulapati, S.; Conroy, M.; Cortina, C.; Harding, E.; Kamaraju, S. Systematic Review on Gender-Affirming Testosterone Therapy and the Risk of Breast Cancer: A Challenge for Physicians Treating Patients from Transgender and Gender-Diverse Populations. Arch. Sex. Behav. 2024 , 53 , 1969–1980. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Schagen, S.E.E.; Wouters, F.M.; Cohen-Kettenis, P.T.; Gooren, L.J.; Hannema, S.E. Bone Development in Transgender Adolescents Treated With GnRH Analogues and Subsequent Gender-Affirming Hormones. J. Clin. Endocrinol. Metab. 2020 , 105 , e4252–e4263. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Verroken, C.; Collet, S.; Lapauw, B.; T’Sjoen, G. Osteoporosis and Bone Health in Transgender Individuals. Calcif. Tissue Int. 2022 , 110 , 615–623. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Venkatesh, V.S.; Nie, T.; Zajac, J.D.; Grossmann, M.; Davey, R.A. The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy. Curr. Osteoporos. Rep. 2023 , 21 , 825–841. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Rothman, M.S.; Iwamoto, S.J. Bone Health in the Transgender Population. Clin. Rev. Bone Miner. Metab. 2019 , 17 , 77–85. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Rosen, H.N.; Hamnvik, O.R.; Jaisamrarn, U.; Malabanan, A.O.; Safer, J.D.; Tangpricha, V.; Wattanachanya, L.; Yeap, S.S. Bone Densitometry in Transgender and Gender Non-Conforming (TGNC) Individuals: 2019 ISCD Official Position. J. Clin. Densitom. 2019 , 22 , 544–553. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Shuhart, C.R.; Yeap, S.S.; Anderson, P.A.; Jankowski, L.G.; Lewiecki, E.M.; Morse, L.R.; Rosen, H.N.; Weber, D.R.; Zemel, B.S.; Shepherd, J.A. Executive Summary of the 2019 ISCD Position Development Conference on Monitoring Treatment, DXA Cross-calibration and Least Significant Change, Spinal Cord Injury, Peri-prosthetic and Orthopedic Bone Health, Transgender Medicine, and Pediatrics. J. Clin. Densitom. 2019 , 22 , 453–471. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • van Leerdam, T.R.; Zajac, J.D.; Cheung, A.S. The Effect of Gender-Affirming Hormones on Gender Dysphoria, Quality of Life, and Psychological Functioning in Transgender Individuals: A Systematic Review. Transgender Health 2023 , 8 , 6–21. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Bouck, E.G.; Grinsztejn, E.; Mcnamara, M.; Stavrou, E.X.; Wolberg, A.S. Thromboembolic risk with gender-affirming hormone therapy: Potential role of global coagulation and fibrinolysis assays. Res. Pract. Thromb. Haemost. 2023 , 7 , 102197. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Aranda, G.; Halperin, I.; Gomez-Gil, E.; Hanzu, F.A.; Seguí, N.; Guillamon, A.; Mora, M. Cardiovascular Risk Associated With Gender Affirming Hormone Therapy in Transgender Population. Front. Endocrinol. 2021 , 12 , 718200. [ Google Scholar ] [ CrossRef ] [ PubMed ] [ PubMed Central ]
  • Cheung, A.S.; Nolan, B.J.; Zwickl, S. Transgender health and the impact of aging and menopause. Climacteric 2023 , 26 , 256–262. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Lucas-Herald, A.K.; Bashamboo, A. Gonadal development. Endocr. Dev. 2014 , 27 , 1–16. [ Google Scholar ] [ CrossRef ] [ PubMed ]
  • Available online: https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/kunskapsstod/2023-1-8330.pdf (accessed on 2 July 2024).

Click here to enlarge figure

Tanner StagePubic Hair (Male and Female)Breast Development (Females)Testicular Volume (Males)
1No hairNo glandular breast tissue palpableTesticular volume < 4 mL or long axis < 2.5 cm
2Downy hairBreast bud palpable under the areola (1st pubertal sign in females)4–8 mL (or 2.5 to 3.3 cm long), 1st pubertal sign in males
3Scant terminal hairBreast tissue palpable outside areola; no areolar development9–12 mL (or 3.4 to 4.0 cm long)
4Terminal hair that fills the entire triangle overlying the pubic regionAreola elevated above the contour of the breast, forming a “double scoop” appearance15–20 mL (or 4.1 to 4.5 cm long)
5Terminal hair that extends beyond the inguinal crease onto the thighAreolar mound recedes into single breast contour with areolar hyperpigmentation, papillae development, and nipple protrusion>20 mL (or >4.5 cm long)
GuidelinesSociety of EndocrinologyThe World Professional Association for Transgender Health (WPATH)Australian Professional Association for Trans Health (AusPATH)
Evaluation of prospective patientsClinicians can add gender-affirming hormones after multidisciplinary team (MDT) team has confirmed the persistence of GI and sufficient mental capacity to give informed consent to treatment. The clinicians and mental health practitioners must be trained to diagnose GI.Health care professionals have competencies in the assessment of transgender and gender diverse people wishing gender-related medical treatment and consider the role of social transition together with the individual.
Liaise with professionals from different disciplines within the field of transgender health prior to gender-affirming treatment
Treatment Unless there is agreement among the parents, the adolescent, and medical practitioner regarding competence, diagnosis, and treatment, a Family Court order is required for access to gender-affirming puberty blockers, hormone treatment, and surgery for adolescents under 18 years old.
Puberty
Induction
Regimen
Transgender AMAB people: Increasing doses of oral or transdermal 17β-estradiol, until adult dosage is reached. In postpubertal transgender AMAB people, the dose is increased more rapidly.
Transgender AFAB people: Increasing doses of testosterone until adult values are reached. In postpubertal males, the dose is increased more rapidly.
Adult maintenance dose is to mimic physiological adult levels.
In eligible youth who have reached the early stages of puberty, the aim is to delay further pubertal progression with GnRHas until an appropriate time when GAHT can be introduced. In these cases, pubertal suppression is considered medically necessary.
Treatment of transgender AFAB/AMAB peopleTransgender AFAB people: treatment with both parenteral and transdermal testosterone
Transgender AMAB people: Oral, transdermal or parenteral oestrogen. Antiandrogens: spironolactone, cyproterone acetate, GnRH agonist. Estradiol and testosterone are maintained at premenopausal female levels.
Gender-affirming hormones are maintained at normal adult ranges
Transgender AFAB people:
Masculinising treatment, usually with testosterone.
Transgender AMAB people: treatment is usually with oestrogen and androgen-lowering medication.
Transgender AFAB people: masculinising treatment is with different formulations of testosterone
Transgender AMAB people: Feminising treatment includes oestrogen and androgen blockers. It is usual to start with low doses and titrate upwards.
MonitoringPeriodic monitoring of hormone levels, metabolic parameters, and assessment of prostate gland, gonads, and uterus as well as bone densityHormone levels are measured during gender-affirming treatment to ensure endogenous sex steroids are lowered and administered sex steroids are maintained at levels appropriate for the treatment goals of transgender people according to the Tanner stage.
For masculinising treatment, total testosterone levels are maintained at the lower male reference range, and for feminising treatment, estradiol is aimed to be within the female reference range.
Reference[ ][ ][ , ]
Clinical Chemistry TestsOther Tests
LH, FSH, E2/T, 25(OH)DAnthropometry: height, weight, blood pressure, Tanner stages
Suggested Interval6–12 months3–6 months
Bone density using DXA
Suggested Interval 1–2 years
Reference [ ]
Laboratory TestsOther Tests
Transgender AFAB peopleTMonitor for virilization
Suggested Interval3 monthly until levels within adult rangeEvery 3 months the first year and then one or two times per year
Haematocrit or haemoglobinScreening for osteoporosis, cervical screening (if cervical tissue present), breast cancer screening as recommended
Suggested Interval3 monthly for first year then one/two times per year
Lipids at regular intervals
Transgender AFAM peopleSerum T and estradiolFeminisation
Suggested IntervalEvery 3 monthsEvery 3 months the first year and then one or two times per year
If treated with spironolactone, electrolytesRoutine cancer screening and bone density
Every 3 months the first year and then annually
Reference [ ]
The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

Ramasamy, I. Gender Reassignment and the Role of the Laboratory in Monitoring Gender-Affirming Hormone Therapy. J. Clin. Med. 2024 , 13 , 5134. https://doi.org/10.3390/jcm13175134

Ramasamy I. Gender Reassignment and the Role of the Laboratory in Monitoring Gender-Affirming Hormone Therapy. Journal of Clinical Medicine . 2024; 13(17):5134. https://doi.org/10.3390/jcm13175134

Ramasamy, Indra. 2024. "Gender Reassignment and the Role of the Laboratory in Monitoring Gender-Affirming Hormone Therapy" Journal of Clinical Medicine 13, no. 17: 5134. https://doi.org/10.3390/jcm13175134

Article Metrics

Article access statistics, further information, mdpi initiatives, follow mdpi.

MDPI

Subscribe to receive issue release notifications and newsletters from MDPI journals

IMAGES

  1. How Gender Reassignment Surgery Works (Infographic)

    gender confirmation surgery vs gender reassignment

  2. Gender Confirmation Surgery

    gender confirmation surgery vs gender reassignment

  3. Everything you need to know about the gender affirmation surgery

    gender confirmation surgery vs gender reassignment

  4. Stunning Before And After Photos Depict The Journey Of Gender

    gender confirmation surgery vs gender reassignment

  5. Male To Female Gender Reassignment Surgery

    gender confirmation surgery vs gender reassignment

  6. Stunning Before And After Photos Depict The Journey Of Gender

    gender confirmation surgery vs gender reassignment

VIDEO

  1. 5 Things to Know Before Having SRS, GCS

  2. This patient insisted on gender confirmation surgery.#movie #viral #shorts

  3. My Gender Reassignment Surgery (Crossdressing Story)

  4. Gender-Affirming Surgery: From Outie to Innie

  5. Gender-Affirming Surgery: The Aftermath and Recovery

  6. ‘Giving Birth Vs Sex Reassignment Surgery // Recovery Differences. #mtf #transgender #debate #lgbt

COMMENTS

  1. Gender Confirmation (Formerly Reassignment) Surgery: Procedures

    For some transgender people, gender confirmation surgery is an important and affirming part of the transition process. It can help alleviate feelings of dysphoria, align your body with your ...

  2. Feminizing surgery

    Overview. Feminizing surgery, also called gender-affirming surgery or gender-confirmation surgery, involves procedures that help better align the body with a person's gender identity. Feminizing surgery includes several options, such as top surgery to increase the size of the breasts. That procedure also is called breast augmentation.

  3. Gender Confirmation Surgery

    The cost of transitioning can often exceed $100,000 in the United States, depending upon the procedures needed. A typical genitoplasty alone averages about $18,000. Rhinoplasty, or a nose job, averaged $5,409 in 2019. Insurance Coverage for Sex Reassignment Surgery.

  4. Analyzing Your Gender Reassignment Surgery ...

    The WPATH's SOC 8 reviews the medical research literature around the long-term effects of gender-affirming surgery on trans and non-binary patients. Gender-affirming procedures report greater satisfaction and lower regret rates compared to similar cosmetic and reconstructive procedures performed in cisgender patients. Improved mental health.

  5. Gender Affirmation Surgeries: Common Questions and Answers

    Gender affirmation surgery, also known as gender confirmation surgery, is performed to align or transition individuals with gender dysphoria to their true gender. A transgender woman, man, or non-binary person may choose to undergo gender affirmation surgery. The term "transexual" was previously used by the medical community to describe people ...

  6. Gender-affirming surgery

    Gender-affirming surgery is a surgical procedure, or series of procedures, that alters a person's physical appearance and sexual characteristics to resemble those associated with their identified gender.The phrase is most often associated with transgender health care and intersex medical interventions, although many such treatments are also pursued by cisgender and non-intersex individuals.

  7. Gender Confirmation Surgeries

    Gender confirmation surgeries, also known as gender affirmation surgeries, are performed by a multispecialty team that typically includes board-certified plastic surgeons. The goal is to give transgender individuals the physical appearance and functional abilities of the gender they know themselves to be. Listed below are many of the available ...

  8. Transgender Surgeries & Gender Affirmation

    Gender Affirming Surgeries. For those patients who choose to have gender-affirming surgery, the Mount Sinai Center for Transgender Medicine and Surgery can help. These procedures may also be referred to as gender reassignment or confirmation procedures. We are among the world's leaders in this field, performing several hundred surgeries each ...

  9. Gender Affirming Surgery

    Gender affirming surgery, also known as sex reassignment surgery (SRS) or confirmation surgery, is the surgical procedure(s) by which a transgender or non-binary person&amp;rsquo;s physical appearance and functional abilities are changed to align with the gender they know themselves to be.

  10. Preparing for Gender Affirmation Surgery: Ask the Experts

    Request an Appointment. 410-955-5000 Maryland. 855-695-4872 Outside of Maryland. +1-410-502-7683 International. To help provide guidance for those considering gender affirmation surgery, two experts from the Johns Hopkins Center for Transgender Health answer questions about what to expect before and after your surgery.

  11. Gender Affirmation Surgeries

    Top surgery is surgery that removes or augments breast tissue and reshapes the chest to create a more masculine or feminine appearance for transgender and nonbinary people. Facial gender surgery: While hormone replacement therapy can help achieve gender affirming changes to the face, surgery may help. Facial gender surgery can include a variety ...

  12. Gender Confirmation Surgery

    Individuals who desire surgical procedures who have not been part of the Comprehensive Gender Services Program should contact the program office at (734) 998-2150 or email [email protected]. We will assist you in obtaining what you need to qualify for surgery. University of Michigan Comprehensive Gender Services Program brings ...

  13. Gender-Affirming Surgery: A Comprehensive Guide

    A Comprehensive Guide to Gender-Affirming Surgery. Medically reviewed by Paul Gonzales on April 15, 2024.. Gender-affirming surgery is an umbrella term for a series of surgical procedures that help transgender, non-binary and gender non-confirming individuals alleviate their gender dysphoria and promote a sense of congruence between their physical body and gender identity.

  14. PDF Sex reassignment surgery (gender affirmation surgery, gender

    Gender identity: A category of social identity that refers to an individual's identification as male, female or, occasionally, some other category other than male or female. Gender reassignment: A change of gender that can be either medical (hormones, surgery) or legal (government recognition), or both.

  15. Surgery for Transgender People: Learn About Gender Affirmation

    A trans person can choose from multiple procedures to make their appearance match their self-identified gender identity. Doctors refer to this as gender "affirmation" surgery. Trans people might ...

  16. Gender Confirmation Surgery

    Request an Appointment. Call 215-662-7300 or request an appointment online. Penn Medicine proudly offers gender confirmation surgery, also known as gender affirmation surgery, to help align your identity.

  17. Gender Affirmation Surgery

    Gender affirmation surgery (previously gender confirmation surgery) for individuals looking to transition: transfeminine or transmasculine. These can include mastectomy and phalloplasty/bottom surgery or breast augmentation, facial feminization, and vaginoplasty/bottom surgery. Learn more about your options.

  18. Gender reassignment surgery: an overview

    Introduction. Gender reassignment surgery is indicated for the treatment of gender dysphoria. Patients who suffer gender dysphoria feel that their birth gender is somehow 'wrong' and seek to adopt ...

  19. $91,850 Hospital Bill For Gender-Confirmation Surgery Comes As A ...

    Patient: Wren Vetens, then 23, a Ph.D. student at the University of Wisconsin-Madison. Total bill: $91,850.20. Insurance payment: $25,427.91. Vetens owed: $13,191.95 (after $20,080 that was ...

  20. Insurance Coverage for Transgender Surgery

    Insurance Coverage for Gender-Affirming Surgery Medically reviewed by Paul Gonzales on March 13, 2024. Navigating insurance coverage for gender affirmation surgery can be complex, but many insurance providers now recognize these forms of healthcare for transgender individuals as medically necessary and thereby deserving of coverage. This guide aims to simplify the process of finding and ...

  21. FACT CHECK: Is The Rate Of Regret After Gender-Affirming Surgery Only 1%?

    Fact Check: The Instagram post claims that only 1% of patients regret their gender transition surgeries. The source used is "Regret after Gender-affirmation Surgery: A systematic Review and Meta-analysis of Prevalence" from the National Library of Medicine (NLM). The caption is misleading, due to several factors and lack of research that ...

  22. Health Insurers Hit With CA's Largest-Ever Penalty Over Gender ...

    The department in 2017 issued a $200,000 fine against the insurer Health Net for gaps in coverage related to gender reassignment surgery and other procedures. Most recently, ... In this month's case, regulators said the insurance companies must also provide written confirmation that they have modified their rules, ensured further denials ...

  23. JCM

    Transgender people experience distress due to gender incongruence (i.e., a discrepancy between their gender identity and sex assigned at birth). Gender-affirming hormone treatment (GAHT) is a part of gender reassignment treatment. The therapeutic goals of the treatment are to develop the physical characteristics of the affirmed gender as far as possible. Guidelines have been developed for GAHT ...